Could the mosaic pattern of chromosomal abnormality predict overall survival of patients with myelodysplastic syndrome?

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dc.authorscopusid16426248700
dc.authorscopusid7004457653
dc.authorscopusid57078313300
dc.authorscopusid56640981200
dc.authorscopusid9537275000
dc.authorscopusid54887131700
dc.authorscopusid26030049400
dc.contributor.authorUyanik M.S.
dc.contributor.authorDemir A.M.
dc.contributor.authorKurt I.
dc.contributor.authorMaden M.
dc.contributor.authorOz Puyan F.
dc.contributor.authorGurkan H.
dc.contributor.authorUmit E.G.
dc.date.accessioned2024-06-12T10:25:01Z
dc.date.available2024-06-12T10:25:01Z
dc.date.issued2016
dc.description.abstractObjective/background Myelodysplastic syndromes (MDSs) are a group of monoclonal hematopoietic diseases consisting of a number of various entities. The presence of differences in chromosomal content of cells within the same individual is known as chromosomal mosaicism. The impact of mosaic pattern on the prognosis of MDS has been unclear. In this study, we aimed to determine the impact of mosaic pattern on the survival of patients with MDS. Methods We retrospectively evaluated 119 patients diagnosed with MDS at the Trakya University Faculty of Medicine, Department of Hematology. Giemsa-Trypsin-Giemsa banding was used to evaluate chromosomal abnormality. The effect of chromosomal abnormality mosaicism on overall survival and transformation to acute leukemia was evaluated by Kaplan-Meier survival analysis. Results The mean age at diagnosis was 66.3 years, and the mean disease duration was 24.2 months. Chromosomal abnormality was observed in 32.5% of patients. Patients with chromosomal abnormalities comprising at least 50% metaphases had significantly lower overall survival than patients with abnormality comprising up to 50% of all abnormal metaphases (p =.003). There were no differences in transformation to acute leukemia among patients with higher and lower chromosomal mosaicism (p =.056). Conclusion The most important outcome of this study was to demonstrate worse overall survival rates in MDS patients with higher abnormal chromosomal mosaicism than patients with lesser abnormal chromosomal mosaicism. Higher levels of abnormal chromosomal mosaicism did not predict transformation to acute leukemia. The cause of worse outcomes of patients with higher abnormal chromosomal mosaicism may be related to clonal mass. © 2016 King Faisal Specialist Hospital & Research Centre.Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.hemonc.2015.12.002
dc.identifier.endpage47en_US
dc.identifier.issn1658-3876
dc.identifier.issue2en_US
dc.identifier.pmid26806462en_US
dc.identifier.scopus2-s2.0-84955575504en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1016/j.hemonc.2015.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16155
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKing Faisal Specialist Hospital and Research Centreen_US
dc.relation.ispartofHematology/ Oncology and Stem Cell Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChromosomal Abnormality; Mosaicism; Myelodysplastic Syndrome; Prognosisen_US
dc.subjectAntineoplastic Agent; Eltrombopag; Erythropoietin; Hypomethylating Agent; Iron Chelating Agent; Thalidomide; Trypsin; Unclassified Drug; Acute Leukemia; Aged; Article; Blood Transfusion; Breast Carcinoma; Cancer Mortality; Cancer Radiotherapy; Chromosome Aberration; Chromosome Banding Pattern; Clonal Variation; Controlled Study; Disease Association; Disease Classification; Disease Duration; Female; Genetic Transformation; Giemsa Stain; Hodgkin Disease; Human; Kaplan Meier Method; Major Clinical Study; Male; Malignant Transformation; Metaphase; Mosaicism; Multivariate Analysis; Myelodysplastic Syndrome; Overall Survival; Palliative Therapy; Retrospective Study; Very Elderly; Adult; Chromosome Aberration; Demography; Genetics; Karyotyping; Middle Aged; Mosaicism; Myelodysplastic Syndrome; Pathology; Survival Analysis; World Health Organization; Adult; Aged; Aged, 80 And Over; Chromosome Aberrations; Demography; Female; Humans; Karyotyping; Male; Metaphase; Middle Aged; Mosaicism; Myelodysplastic Syndromes; Survival Analysis; World Health Organizationen_US
dc.titleCould the mosaic pattern of chromosomal abnormality predict overall survival of patients with myelodysplastic syndrome?en_US
dc.typeArticleen_US

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