Effects of L-carnitine on long-term post renal ischemia and reperfusion injury in rat

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dc.authorscopusid6602427108
dc.authorscopusid7006356462
dc.authorscopusid7005037316
dc.authorscopusid12786699400
dc.authorscopusid6507384252
dc.contributor.authorAydo?du N.
dc.contributor.authorKanter M.
dc.contributor.authorYalçin Ö.
dc.contributor.authorTaştekin E.
dc.contributor.authorKaymak K.
dc.date.accessioned2024-06-12T10:26:33Z
dc.date.available2024-06-12T10:26:33Z
dc.date.issued2013
dc.description.abstractObjective: Free radicals and nitric oxide play an important role in the pathogenesis of acute kidney injury (AKI) induced by ischemia and reperfusion (IR). Despite the protective effects of L-carnitine on renal ischemia reperfusion injury, reports are lacking on its effects on anemia and the erythrocyte antioxidant status of long-term post IR injury in the rat kidney. In the present study, we aimed to investigate the effects of L-carnitine on long-term IR injury in rat kidney. Material and Methods: Male Wistar Albino rats were divided into three groups (eight rats each) as Sham, IR (60 minutes of bilateral ischemia and 168 hours reperfusion) and IR+L-carnitine (intraperitoneally; 300 mg/kg/day for 7 days) groups. Anemia, kidney function, lipid peroxidation and kidney and erythrocyte antioxidant enzyme activities as well as expression of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) were examined. The kidneys were histologically evaluated. Results: L-carnitine treatment attenuated IR-induced histological alteration and reduced iNOS activitiy, increased eNOS activity, reduced urea and creatinine (each p=0.001), decreased malondialdehide levels (p=0.001) and increased both kidney and erythrocyte antioxidant enzymes activitiy and glutathione levels (p=0.001). Hematocrit was significantly increased (p=0.038). Conclusion: Our results show that L-carnitine plays a protective role in the pathogenesis of renal injury induced by IR. In addition, L-carnitine may ameliorate the anemia observed after renal IR injury. © 2013 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2012-32674
dc.identifier.endpage887en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84879146577en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage879en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2012-32674
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16882
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemia; Carnitine; Kidney; Oxidative Stress; Reperfusion Injuryen_US
dc.subjectCarnitine; Catalase; Creatinine; Endothelial Nitric Oxide Synthase; Glutathione; Glutathione Peroxidase; Inducible Nitric Oxide Synthase; Urea; Anemia; Animal Cell; Animal Experiment; Animal Model; Animal Tissue; Article; Controlled Study; Drug Effect; Enzyme Activity; Erythrocyte; Hematocrit; Histopathology; Kidney Function; Kidney Injury; Kidney Ischemia; Lipid Peroxidation; Male; Nonhuman; Protein Expression; Rat; Reperfusion Injury; Sham Procedure; Treatment Duration; Wistar Albino Glaxo Raten_US
dc.titleEffects of L-carnitine on long-term post renal ischemia and reperfusion injury in raten_US
dc.title.alternativeSıçanlarda uzun süreli böbrek İskemisi ve reperfüzyon hasarında L-karnitinin etkilerien_US
dc.typeArticleen_US

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