İnflamatuvar bağırsak hastalığı olgularımızın erişkin aşılama programı hakkındaki bilgi düzeyleri ve aşılanma oranları
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
İnflamatuvar bağırsak hastalıkları gastrointestinal kanalın alevlenmeler ve remisyonlarla seyreden kronik patolojileridir. Hastalığın tedavisinde immunmodulatörler (azatiopurin, 6-merkaptopurin vb), biyolojik ajanlar (anti-tümör nekroz faktörler, anti integrinler vb) kullanılmaktadır. Bu ajanlar bir taraftan immun yanıtı baskılarken, diğer yandan olguları her çeşit infeksiyona açık hale getirmektedir. Çalışmamızın amacı Trakya Üniversitesi Tıp Fakültesi İç Hastalıkları Ana Bilim Dalı Gastroenteroloji Bilim Dalı tarafından takip edilen inflamatuvar bağırsak hastalıkları olgularının erişkin aşılanma takvimi konusunda bilgi düzeyleri, aşılanma oranları ve aşılanma sonrası antikor yanıt oranlarının değerlendirilmesidir. Bu çalışmada yöntem olarak; inflamatuvar bağırsak hastalıkları olgularında erişkin aşılama programında yer alan aşılar ilişkili anket biçiminde 31 soru ve aşılama sonucu gelişen bağışıklık yanıtının retrospektif olarak taranarak değerlendirilmesi planlanmıştır. Çalışmaya dâhil edilen 137 hastanın 72'si (%52,5) ülseratif kolit, 65'i (%47,4) crohn hastalığı tanısı olduğu saptanmıştır. Olgularımızın 81'ine (%59,1) aşı konusunda yeterli önerilerde bulunulmadığı, 123 (%89,9) olgunun eksik olan aşıları konusunda aşılanması gerektiğinden haberdar olmadığı saptandı. Hastalarımızın en sıklıkla olduğu aşılar Covid-19 (%92), Tetanoz-Difteri (%56,2), Hepatit-B (%37,2), İnfluenza (%19,7) olarak saptandı. Aşılanan hastalar incelendiğinde 48 (%35) hastanın gastroenteroloji hekimi tarafından aşılamaya yönlendirildiği saptandı. Anket sonunda 133 (%97,1) hastanın aşı olmayı düşündüğü saptandı. Sonuç olarak inflamatuvar bağırsak hastalıkları hastalarının aşılanma oranlarını immunsupresyon durumları, biyolojik ajan maruziyeti, yaş ortalaması, kronik hastalık öyküsü, eğitim durumu, ikamet yeri gibi çeşitli faktörlerin belirlediği saptandı. Düşünülenin aksine immunsupresyon durumunda olan hastaların aşı sonrası antikor yanıtı oluşturduğu saptandı. İnflamatuvar bağırsak hastalıkları hastalarının fırsatçı enfeksiyonlardan korunması için aşılama programlarına alınması ile ilgili güncel çalışmalar ile beraber hem hekimlerin hem de hastaların aşılanma konusunda farkındalığının ve hastaların aşılanma oranlarının artacağını düşünüyoruz. Anahtar Kelimeler: İnflamatuvar bağırsak hastalığı, Crohn Hastalığı, Ülseratif Kolit, Aşılama
Inflammatory bowel diseases are chronic pathologies of the gastrointestinal tract with exacerbations and remissions. In the treatment of the disease, immunomodulators (azathiopurine, 6-mercaptopurine, etc.), biological agents (anti-tumor necrosis factors, anti integrins, etc.) are used. While these agents suppress the immune response on the one hand, they make the cases vulnerable to all kinds of infections, on the other. The aim of our study is to evaluate the knowledge levels, vaccination rates and post vaccination antibody response rates of inflammatory bowel disease cases followed by Trakya University Faculty of Medicine, Department of Internal Medicine, Department of Gastroenterology. As a method in this study; In inflammatory bowel disease cases, it was planned to retrospectively scan and evaluate 31 questions in the form of a questionnaire related to vaccines in the adult vaccination program and the immune response developed as a result of vaccination. Of the 137 patients included in the study, 72 (52.5%) were diagnosed with ulcerative colitis and 65 (47.4%) were diagnosed with Crohn's disease. It was determined that 81 (59.1%) of our cases did not receive adequate recommendations on vaccination, and 123 (89.9%) cases were not aware of the need to be vaccinated about their missing vaccines. The vaccines most frequently used by our patients were Covid-19 (92%), Tetanus-Diphtheria (56.2%), Hepatitis-B (37.2%), Influenza (19.7%). When the vaccinated patients were examined, it was determined that 48 (35%) patients were referred for vaccination by the gastroenterology physician. At the end of the questionnaire, it was determined that 133 (97.1%) patients were considering vaccination. As a result, it was determined that the vaccination rates of inflammatory bowel disease patients were determined by various factors such as immunosuppression status, exposure to biological agents, average age, chronic disease history, education level, and place of residence. Contrary to what was thought, it was determined that patients with immunosuppression developed an antibody response after vaccination. We think that the awareness of both physicians and patients about vaccination and the vaccination rates of patients will increase with the current studies on the inclusion of inflammatory bowel disease patients in vaccination programs to protect them from opportunistic infections. Keywords: Inflammatory bowel disease, Crohn's Disease, Ulcerative Colitis, Vaccination
Inflammatory bowel diseases are chronic pathologies of the gastrointestinal tract with exacerbations and remissions. In the treatment of the disease, immunomodulators (azathiopurine, 6-mercaptopurine, etc.), biological agents (anti-tumor necrosis factors, anti integrins, etc.) are used. While these agents suppress the immune response on the one hand, they make the cases vulnerable to all kinds of infections, on the other. The aim of our study is to evaluate the knowledge levels, vaccination rates and post vaccination antibody response rates of inflammatory bowel disease cases followed by Trakya University Faculty of Medicine, Department of Internal Medicine, Department of Gastroenterology. As a method in this study; In inflammatory bowel disease cases, it was planned to retrospectively scan and evaluate 31 questions in the form of a questionnaire related to vaccines in the adult vaccination program and the immune response developed as a result of vaccination. Of the 137 patients included in the study, 72 (52.5%) were diagnosed with ulcerative colitis and 65 (47.4%) were diagnosed with Crohn's disease. It was determined that 81 (59.1%) of our cases did not receive adequate recommendations on vaccination, and 123 (89.9%) cases were not aware of the need to be vaccinated about their missing vaccines. The vaccines most frequently used by our patients were Covid-19 (92%), Tetanus-Diphtheria (56.2%), Hepatitis-B (37.2%), Influenza (19.7%). When the vaccinated patients were examined, it was determined that 48 (35%) patients were referred for vaccination by the gastroenterology physician. At the end of the questionnaire, it was determined that 133 (97.1%) patients were considering vaccination. As a result, it was determined that the vaccination rates of inflammatory bowel disease patients were determined by various factors such as immunosuppression status, exposure to biological agents, average age, chronic disease history, education level, and place of residence. Contrary to what was thought, it was determined that patients with immunosuppression developed an antibody response after vaccination. We think that the awareness of both physicians and patients about vaccination and the vaccination rates of patients will increase with the current studies on the inclusion of inflammatory bowel disease patients in vaccination programs to protect them from opportunistic infections. Keywords: Inflammatory bowel disease, Crohn's Disease, Ulcerative Colitis, Vaccination
Açıklama
Tıpta Uzmanlık
Anahtar Kelimeler
Gastroenteroloji, Gastroenterology ; İç Hastalıkları
