Immunoglobulin concentration in human intervertebral disc herniations

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dc.authoridDEMIR, Mehmet/0000-0001-5942-3751
dc.authorwosidDEMIR, Mehmet/AAH-2121-2019
dc.contributor.authorGörgülü, A
dc.contributor.authorYalniz, E
dc.contributor.authorDemir, M
dc.contributor.authorÇobanoglu, S
dc.date.accessioned2024-06-12T11:07:08Z
dc.date.available2024-06-12T11:07:08Z
dc.date.issued1999
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe pathogenesis of low back pain and sciatica is poorly understood. In this prospective study, we determined local production of IgM and IgG in nucleus pulposus, serum and cerebrospinal fluid by rate nephelometry in patients with herniated lumbar disc (n = 20). Patients operated for anterior stabilizations because of fresh fracture in the lumbar or thoracolumbar spine and scoliosis constituted the control group (n = 10). In the patients with lumbar disc herniation, the ratio IgM(NP)/IgM(S) x 10(3), IgG(CSF)/IgG(S) x 10(3), and IgM(CSF)/IgM, x 103 was significantly increased when compared with control group values (p < 0.001). We found a close relationship of the ratio IgM(NP)/IgM(S) x 10(3) between low SLR (<40 degrees) (p = 0.02) and the duration of sciatric pain less than 2 months (p = 0.002). The results indicate a connection between the clinical findings and IgM production in nucleus pulposus. This fact may contribute in some way to the inflammatory origin of sciatica.en_US
dc.identifier.endpage48en_US
dc.identifier.issn0177-7955
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0033452493en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21922
dc.identifier.volume26en_US
dc.identifier.wosWOS:000084203500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofNeuro-Orthopedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunuglobulinsen_US
dc.subjectNucleus Pulposusen_US
dc.subjectSciaticaen_US
dc.subjectNucleus Pulposusen_US
dc.subjectPainen_US
dc.titleImmunoglobulin concentration in human intervertebral disc herniationsen_US
dc.typeArticleen_US

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