Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:15:40Z
dc.date.available2024-06-12T11:15:40Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and thymoquinone (TQ) on histopathological changes of sciatic nerves in streptozotocin-induced diabetic rats. The rats were randomly allotted into one of four experimental groups: A (control), B (diabetic untreated), C (diabetic treated with NS) and D (diabetic treated with TQ); each group contain ten animals. B, C and D groups received streptozotocin (STZ) to induce diabetes. The rats in NS and TQ treated groups were given NS (in a dose of 400 mg/kg body weight) and TQ (50 mg/kg body weight) once a day orally by using intra-gastric intubation for 12 weeks starting 2 days after STZ injection, respectively. Blood and tissue samples were obtained for biochemical and histopathological investigation. The treatment of both NS and TQ caused a sharp decrease in the elevated serum glucose (P < 0.01, 0.05, respectively), and an increase in the lowered serum insulin concentrations (P < 0.01, 0.05, respectively), in STZ-induced diabetic rats. STZ induced a significant decrease in the area of insulin immunoreactive beta-cells (P < 0.0001). NS (P < 0.001) and TQ (P < 0.01) treatment resulted in increased area of insulin immunoreactive beta-cells significantly. To date, no histopathological changes of sciatic nerves in STZ induced diabetic rats by NS and TQ treatment have been reported. In this study, histologic evaluation of the tissues in diabetic animals treated with TQ and especially NS showed fewer morphologic alterations. Myelin breakdown decreased significantly after treatment with NS and TQ. The ultrastructural features of axons also showed remarkable improvement. We believe that further preclinical research into the utility of NS and TQ may indicate its usefulness as a potential treatment on peripheral neuropathy (PN) in STZ induced diabetic rats.en_US
dc.identifier.doi10.1007/s11064-007-9419-5
dc.identifier.endpage96en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue1en_US
dc.identifier.pmid17713854en_US
dc.identifier.scopus2-s2.0-36949037103en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-007-9419-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24025
dc.identifier.volume33en_US
dc.identifier.wosWOS:000251521300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectNigella Sativaen_US
dc.subjectThymoquinoneen_US
dc.subjectMorphologyen_US
dc.subjectSciatic Nerveen_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectEndoneurial Blood-Flowen_US
dc.subjectNf-Kappa Ben_US
dc.subjectPeripheral-Nerveen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectNeurovascular Functionen_US
dc.subjectAldose Reductaseen_US
dc.subjectOxidative Stressen_US
dc.subjectOxygen-Tensionen_US
dc.subjectPolyol Pathwayen_US
dc.subjectStreptozotocinen_US
dc.titleEffects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathyen_US
dc.typeArticleen_US

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