Metformin and atorvastatin reduce adhesion formation in a rat uterine horn model

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dc.authoridGungor, Tayfun/0000-0002-7869-9662
dc.authorwosidYilmaz, Bulent/HKE-5048-2023
dc.authorwosidbayraktar, nilufer/Y-8758-2018
dc.authorwosidYilmaz, Bulent/GPK-8613-2022
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorAksakal, Orhan
dc.contributor.authorGungor, Tayfun
dc.contributor.authorSirvan, Levent
dc.contributor.authorSut, Necdet
dc.contributor.authorKelekci, Sefa
dc.contributor.authorSoysal, Sunullah
dc.date.accessioned2024-06-12T10:50:45Z
dc.date.available2024-06-12T10:50:45Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to determine whether atorvastatin and metformin are effective in preventing adhesions in a rat uterine horn model. A total of 40 non-pregnant, female Wistar albino rats, weighing 180-210 g, were used as a model for post-operative adhesion formation. The rats were randomized into four groups after seven standard lesions were inflicted in each uterine horn and lower abdominal sidewall using bipolar cauterization. The rats were given atorvastatin 2.5 mg/kg/day, p.o. (10 rats), atorvastatin 30 mg/kg/day, p.o. (10 rats), metformin 50 mg/kg/day, p.o. (10 rats) and no treatment was applied in the control group (10 rats). The animals were killed 2 weeks later and adhesions were scored both clinically and pathologically by authors blinded to groups. One rat in the control group died before the end of the 2 week period. Total clinical adhesion scores regarding extent, severity and degree of adhesions and histopathological findings including inflammation and fibrosis were significantly lower in the metformin (P < 0.001 and P < 0.01, respectively) and atorvastatin 30 mg/kg/day (P < 0.001 and P < 0.01, respectively) groups when compared with control group. Metformin and atorvastatin are both effective for prevention of adhesion formation in a rat uterine horn model.en_US
dc.identifier.doi10.1016/S1472-6483(10)60106-X
dc.identifier.endpage442en_US
dc.identifier.issn1472-6483
dc.identifier.issue3en_US
dc.identifier.pmid19298747en_US
dc.identifier.scopus2-s2.0-63249134729en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.1016/S1472-6483(10)60106-X
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18097
dc.identifier.volume18en_US
dc.identifier.wosWOS:000264455200020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherReproductive Healthcare Ltden_US
dc.relation.ispartofReproductive Biomedicine Onlineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhesion Preventionen_US
dc.subjectAtorvastatinen_US
dc.subjectMetforminen_US
dc.subjectRaten_US
dc.subjectUterine Horn Modelen_US
dc.subjectPlasminogen-Activator Inhibitoren_US
dc.subjectPolycystic-Ovary-Syndromeen_US
dc.subjectL6 Muscle-Cellsen_US
dc.subjectPostoperative Adhesionen_US
dc.subjectHyaluronate/Carboxymethylcellulose Membraneen_US
dc.subjectFibrinolytic-Activityen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectHyaluronic-Aciden_US
dc.subjectRisk-Factorsen_US
dc.subjectPreventionen_US
dc.titleMetformin and atorvastatin reduce adhesion formation in a rat uterine horn modelen_US
dc.typeArticleen_US

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