Maternal serum tumor necrosis factor-? in patients with preterm labor

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dc.contributor.authorGücer, F
dc.contributor.authorBalkanli-Kaplan, P
dc.contributor.authorYüksel, M
dc.contributor.authorYüce, MA
dc.contributor.authorTüre, M
dc.contributor.authorYardim, T
dc.date.accessioned2024-06-12T11:16:44Z
dc.date.available2024-06-12T11:16:44Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate maternal serum tumor necrosis factor-alpha (TNF alpha) levels in patients with preterm labor without clinical signs of chorioamnionitis and to compare these with levels in nonlaboring controls. STUDY DESIGN: The study group consisted of 44 patients with a singleton pregnancy admitted to our department with the diagnosis of preterm labor between 26 and 36 weeks' gestation. The control group consisted of 25 healthy consecutive patients with a singleton pregnancy without preterm contractions who were seen for routine antenatal visits. Maternal serum TNF alpha was measured using a solid-phase, two-site chemiluminescent enzyme immunometric assay method, and levels were compared in patients with preterm labor and nonlaboring controls. RESULTS: The median maternal serum TNF alpha level for patients with preterm labor was 29.4 pg/mL (range, 12.3-173) as compared with 23 pg/mL (range, 11.9-62.7) in the control group (P = .031). Among 44 patients with preterm labor, 14 (32%) delivered within one week of admission. The median maternal serum TNF alpha level was significantly higher in patients who delivered within one week than in those who delivered after one week and controls (71.3 pg/mL [range, 28-173]) versus 22 pg/mL (range, 12.3-86) versus 23 pg/mL (range, 11.9-62.7) (P < .0001). CONCLUSION: TNF was elevated in patients with preterm labor, suggesting a role for maternal serum TNF alpha in its initiation.en_US
dc.identifier.endpage236en_US
dc.identifier.issn0024-7758
dc.identifier.issue3en_US
dc.identifier.pmid11304864en_US
dc.identifier.scopus2-s2.0-0035044139en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24432
dc.identifier.volume46en_US
dc.identifier.wosWOS:000168085500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal Of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.subjectLabor, Prematureen_US
dc.subjectPregnancy Complicationsen_US
dc.subjectAmniotic-Fluiden_US
dc.subjectSpontaneous-Abortionen_US
dc.subjectGestational Tissuesen_US
dc.subjectTermen_US
dc.subjectPregnancyen_US
dc.subjectInterleukin-1en_US
dc.subjectParturitionen_US
dc.subjectExpressionen_US
dc.subjectInfectionen_US
dc.subjectMembranesen_US
dc.titleMaternal serum tumor necrosis factor-? in patients with preterm laboren_US
dc.typeArticleen_US

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