Serviks kanserinde ıl17, CXCR4, CXCL12, CXCR6 ve CXCL16‘nın tümör evresi ile ilişkisi ve bu mediatörlerin prognozu belirleme üzerindeki etkileri
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Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
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Cilt Başlığı
Yayıncı
Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Serviks kanseri, tüm dünyadaki kadınlarda görülen kanserler arasında dördüncü sıradadır. Türkiye’de ise, Sağlık Bakanlığı verilerine göre kadınlarda en sık görülen kanser sıralamasında 9. sırada yer alan önemli bir sağlık sorunudur. Kanser gelişiminde inflamasyon, önemli bir faktördür. İnflamasyonun tümör oluşumunu progrese etmesinin yanında; endojen kaynaklı antiinflamatuvar mekanizmalardaki bozuklukların da tümör gelişimine neden olabileceği belirtilmektedir. Sitokinler ve kemokinler, tümörlerin büyümesini ve invazivliğini değiştirebilmektedir. Tümörlerin immün gözetimine, metastaza, anjiyogeneze ve proliferasyona olan etkileri, dikkatleri bu faktörlere yöneltmektedir. Bu çalışmanın amacı, serviks kanserinde CXCR4, CXCL12, CXCR6, CXCL16 ve IL17‘nin tümör evresi ile ilişkisi ve bu belirteçlerin serviks kanseri için prognostik değerini belirlemektir. Trakya Üniversitesi Tıp Fakültesi Sağlık Araştırma ve Uygulama Hastanesi Kadın Hastalıkları ve Doğum Bölümü’nde Ocak 2008 - Mayıs 2018 tarihleri arasında, serviks kanseri nedeni ile primer operasyonu yapılmış 86 hasta çalışmaya alındı. Hastaların demografik ve prognostik verilerine ulaşıldı. Trakya Üniversitesi Tıp Fakültesi Patoloji Bölümü’nde formalin tespitli, parafine gömülü dokulardan hazırlanan kesitlerde çalışılarak, immunohistokimyasal olarak, bu belirteçlerin varlığı araştırıldı. Evreyle CXCL12 ve CXCR4, IL 17 ve CXCL16 arasında ilişki olmadığı ancak erken evrede CXCR6 düzeylerinde arttığı görüldü. CXCR4 ekspresyonunun grade 2’de anlamlı olarak arttığı görüldü. Sağkalımla CXCL12 ve CXCR4, IL 17 ve CXCR6 arasında ilişki bulunamazken, CXCL16’nın atmış ekspresyonlarında daha uzun hastalıksız ve toplam sağkalım görüldü. CXCL16 vajinal tutulum olmayanlarda, rekürrens izlenmeyenlerde, hayatta olanlarda daha fazla eksprese olduğu görüldü. Sonuç olarak CXCL12, CXCR4 ve IL 17’nin serviks kanserinin prognoz ve evresi ile ilişkili olmadığı, CXCL16 ve CXCR6’nın iyi prognoz ve artmış sağkalımda daha değerli olduğu görüldü. Ancak bunu söylemek için daha geniş gruplarda yapılmış yeni çalışmalara ihtiyaç vardır.
Cervical cancer ranks fourth among all cancers in women in the world, in Turkey, the Ministry of Health data according to the ranking of 9th most common cancer in women is a major health problem in located. Inflammation in cancer development is an important factor. In addition to the progression of inflammation to tumor formation; It has been reported that disorders in endogenous anti-inflammatory mechanisms may cause tumor growth. Cytokines and chemokines can alter the growth and invasiveness of tumors. The effects of tumors on immunostaining, metastasis, angiogenesis and proliferation lead attention to these factors. The aim of this study was to determine the relationship between CXCR4, CXCL12, CXCR6, CXCL16 and IL17 with tumor stage in cervical cancer and the prognostic value of these markers for cervical cancer. In the Department of Obstetrics and Gynecology, Trakya University Medical Faculty Health Research and Practice Hospital, 86 patients who underwent primary surgery due to cervical cancer between January 2008 and May 2018 were included in the study. Demographic and prognostic data were obtained. We investigated the presence of CXCL12, CXCR4, CXCL16, CXCR6 and IL17 in immunohistochemically in the tissues prepared from formalin-fixed, paraffin-embedded tissues in the Department of Pathology of the Trakya University Faculty of Medicine. One of the most important prognostic indicators, the stage was not associated with CXCL12 and CXCR4, IL 17 and CXCL16. However, increased CXCR6 levels at an early stage. CXCR4 expression increased significantly in grade 2 tumors. While there was no association between survival and CXCL12 and CXCR4, IL 17 and CXCR6, the excretion of CXCL16 had longer disease-free and overall survival. CXCL16 was found to be more expressed in survivors, in those without vajinal involvement, in those without recurrence. As a result, CXCL12 and CXCR4, IL 17, were not associated with prognosis and stage of cervical cancer. CXCL16 and CXCR6 were found to be more valuable in good prognosis and increased survival. However, to say this new studies in larger groups are needed.
Cervical cancer ranks fourth among all cancers in women in the world, in Turkey, the Ministry of Health data according to the ranking of 9th most common cancer in women is a major health problem in located. Inflammation in cancer development is an important factor. In addition to the progression of inflammation to tumor formation; It has been reported that disorders in endogenous anti-inflammatory mechanisms may cause tumor growth. Cytokines and chemokines can alter the growth and invasiveness of tumors. The effects of tumors on immunostaining, metastasis, angiogenesis and proliferation lead attention to these factors. The aim of this study was to determine the relationship between CXCR4, CXCL12, CXCR6, CXCL16 and IL17 with tumor stage in cervical cancer and the prognostic value of these markers for cervical cancer. In the Department of Obstetrics and Gynecology, Trakya University Medical Faculty Health Research and Practice Hospital, 86 patients who underwent primary surgery due to cervical cancer between January 2008 and May 2018 were included in the study. Demographic and prognostic data were obtained. We investigated the presence of CXCL12, CXCR4, CXCL16, CXCR6 and IL17 in immunohistochemically in the tissues prepared from formalin-fixed, paraffin-embedded tissues in the Department of Pathology of the Trakya University Faculty of Medicine. One of the most important prognostic indicators, the stage was not associated with CXCL12 and CXCR4, IL 17 and CXCL16. However, increased CXCR6 levels at an early stage. CXCR4 expression increased significantly in grade 2 tumors. While there was no association between survival and CXCL12 and CXCR4, IL 17 and CXCR6, the excretion of CXCL16 had longer disease-free and overall survival. CXCL16 was found to be more expressed in survivors, in those without vajinal involvement, in those without recurrence. As a result, CXCL12 and CXCR4, IL 17, were not associated with prognosis and stage of cervical cancer. CXCL16 and CXCR6 were found to be more valuable in good prognosis and increased survival. However, to say this new studies in larger groups are needed.
Açıklama
Anahtar Kelimeler
Serviks Kanseri, Prognostik Faktörler, CXCL12, CXCR4, CXCL16, CXCR6, IL17, Cervical Cancer, Prognostic Factors, CXCL12, CXCR4, CXCL16, CXCR6, IL17
