Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorKaradag, HC
dc.contributor.authorTamer, M
dc.contributor.authorFirat, Z
dc.contributor.authorAslantas, A
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T10:59:26Z
dc.date.available2024-06-12T10:59:26Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRecent observations suggest the involvement of adenosine in the peripheral antinociceptive effect of amitriptyline in nerve-injury-induced neuropathic pain. The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline. Diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (50 mg/kg), and tactile allodynia was detected by application of von Frey filaments to the ventral surface of the hindpaw. Both systemic (0.5-2.0 mg/kg, i.p.) and peripheral (10-100 nmol, subcutaneously (s.c.)) administration of amitriptyline were found to produce increases in paw withdrawal thresholds, at higher doses. Coadministration of caffeine (5 mg/kg, i.p.; 1500 nmol, s.c.), at doses which produced no effect on its own, partially reversed systemic and local anti-allodynic effects of amitriptyline. These results indicate an anti-allodynic effect of both peripheral and systemic amitriptyline, and suggest the involvement of endogenous adenosine in the action of amitriptyline in this rat model of painful diabetic neuropathy. These data also suggest that topical application of tricyclic antidepressants may be useful in treating neuropathic pain in diabetics. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0304-3940(02)00491-3
dc.identifier.endpage132en_US
dc.identifier.issn0304-3940
dc.identifier.issue2en_US
dc.identifier.pmid12133572en_US
dc.identifier.scopus2-s2.0-0037047482en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1016/S0304-3940(02)00491-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20448
dc.identifier.volume328en_US
dc.identifier.wosWOS:000177520600014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectNeuropathyen_US
dc.subjectPainen_US
dc.subjectAmitriptylineen_US
dc.subjectAdenosineen_US
dc.subjectAllodyniaen_US
dc.subjectTactile Allodyniaen_US
dc.subjectNeuropathic Painen_US
dc.subjectNerve Ligationen_US
dc.subjectModelen_US
dc.subjectAntidepressantsen_US
dc.subjectBlockadeen_US
dc.subjectBrainen_US
dc.titleInvolvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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