On the effect of fosinopril in patients with diabetic neuropathy
Küçük Resim Yok
Tarih
2003
Yazarlar
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Dergi ISSN
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Angiotensin converting enzyme (ACE) inhibitors have been shown to delay the progression of microvascular complications of diabetes mellitus. The effect of fosinopril on diabetic neuropathy over six months was investigated. Methods: Nineteen patients with diabetic neuropathy diagnosed clinically and electromyographically were included into the study. To nine of the patients, 10 mg qd fosinopril was given for six months. For the control group ten age and sex matched patients with diabetic neuropathy were selected. Patients were evaluated initially and after the six months clinically and by electromyographic studies. Endothelial functions such as endothelin-1, fibrinogen and von Willebrand factors were simultaneously measured. Results: No significant difference was found in conduction studies, neuropathy scores and measured endothelial function parameters between and within the groups after six months. Conclusion: Fosinopril at dose of 10 mg qd for six months did not have significant effect on the course of diabetic neuropathy on the patients studied. Double-blinded placebo controlled studies are needed to evaluate the effect of this drug on diabetic neuropathy.
Açıklama
Anahtar Kelimeler
Angiotensin Converting Enzyme (Ace) Inhibitor; Diabetes Mellitus; Diabetic Neuropathy; Fosinopril, Dipeptidyl Carboxypeptidase Inhibitor; Endothelin 1; Fibrinogen; Fosinopril; Von Willebrand Factor; Adult; Age; Article; Clinical Article; Clinical Examination; Controlled Study; Diabetes Mellitus; Diabetic Neuropathy; Disease Association; Disease Course; Dose Response; Drug Effect; Electromyography; Endothelium; Female; Human; Male; Measurement; Microangiopathy; Risk Factor; Sex Difference
Kaynak
Annals of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
12
Sayı
2
