A comparison of vaginal and oral routes in misoprostol administration for cervical priming before hysteroscopy: A prospective randomized double-blind study
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To compare the effectiveness and safety of oral and vaginal routes in misoprostol administration before hysteroscopic procedures. STUDY DESIGN: Sixty eight consecutive patients, who were candidates for hysteroscopic procedure with different indications, were enrolled into this prospective randomized double blind trial. Patients received misoprostol either orally or vaginally. Considering previously published papers, the dosages of misoprostol in the oral and vaginal groups were chosen as 400 ?g and 200 ?g, respectively. Before hysteroscopic procedure, cervical width, assessed by the size of the Hegar dilator was noted and further cervical dilatation was performed if necessary. RESULT(s): The mean cervical width for the oral and vaginal groups were 5.75±2.18 mm (range 0-9.5 mm) and 6.08±1.67 mm (range 2-9.5 mm), respectively (p=0.476). The mean duration of cervical dilatation was 46.94±30.55 seconds (range 7-115 seconds) in the oral and 47.65 ± 30.40 seconds in the vaginal group (range 2-120 seconds), respectively (p=0.092). Uterus perforation occurred in three patients (two in vaginal and one in oral group). CONCLUSION(s): With respect to cervical opening and duration of dilatation, there was no significant difference between the oral and vaginal misoprostol groups. Also, the rate of complications was similar in both groups. There were only minimal side effects so that both administration routes have been well tolerated.
Açıklama
Anahtar Kelimeler
Cervical Dilatation; Hysteroscopy; Misoprostol, Misoprostol; Adult; Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Double Blind Procedure; Drug Effect; Drug Efficacy; Drug Safety; Drug Tolerability; Female; Human; Hysteroscopy; Major Clinical Study; Prospective Study; Randomized Controlled Trial; Side Effect; Treatment Indication; Uterine Cervix; Uterine Cervix Dilatation; Uterus Perforation
Kaynak
Jinekoloji ve Obstetrik Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
18
Sayı
3
