99mTc-sestamibi muscle scintigraphy to assess the response to neuromuscular electrical stimulation of normal quadriceps femoris muscle

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dc.contributor.authorPekindil, Y
dc.contributor.authorSarikaya, A
dc.contributor.authorBirtane, M
dc.contributor.authorPekindil, G
dc.contributor.authorSalan, A
dc.date.accessioned2024-06-12T11:09:10Z
dc.date.available2024-06-12T11:09:10Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Neuromuscular electrical stimulation (NMES) is widely used for improving muscle strength by simultaneous contraction in the prevention of muscle atrophy. Although there exist many clinical methods for evaluating the therapeutic response of muscles, Tc-99m-sestamibi which is a skeletal muscle perfusion and metabolism agent has not previously been used for this purpose. The aim of our work was to ascertain whether Tc-99m-sestamibi muscle scintigraphy is useful in the monitoring of therapeutic response to NMES in healthy women. Methods: The study included 16 women aged between 21 and 45, with a mean age of 32.7 +/- 6.4. Both quadriceps femoris muscles (QFM) of each patient were studied. After randomization to remove the effect of the dominant side, one QFM of each patient was subjected to the NMES procedure for a period of 20 days. NMES was performed with an alternating biphasic rectangular current, from a computed electrical stimulator daily for 23 minutes. After measurement of skinfold thickness over the thigh, pre- and post-NMES girth measurements were assessed in centimeters. Sixty minutes after injections of 555 MBq Tc-99m-sestamibi, static images of the thigh were obtained for 5 minutes. The thigh-to-knee uptake ratio was calculated by semiquantitative analysis and normalized to body surface area (NUR = normalized uptake ratio). Results: The difference between the pre and post NMES NUR values was Significant (1.76 +/- 0.31 versus 2.25 +/- 0.38, p = 0.0000). The percentage (%) increase in NUR values also well correlated with the % increase in thigh girth measurements (r = 0.89, p = 0.0000). Conclusion: These results indicated that Tc-99m-sestamibi muscle scintigraphy as a new tool may be useful in evaluating therapeutic response to NMES.en_US
dc.identifier.doi10.1007/BF02988252
dc.identifier.endpage401en_US
dc.identifier.issn0914-7187
dc.identifier.issue4en_US
dc.identifier.pmid11577769en_US
dc.identifier.scopus2-s2.0-0034741035en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.1007/BF02988252
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22689
dc.identifier.volume15en_US
dc.identifier.wosWOS:000170872300017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Society Nuclear Medicineen_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuromuscular Electrical Stimulationen_US
dc.subjectTc-99m-Sestamibi Scintigraphyen_US
dc.subjectMuscleen_US
dc.subjectTechnetium 99m Sestamibien_US
dc.subjectFiber Typesen_US
dc.subjectNoninvasive Assessmenten_US
dc.subjectLeg Scintigraphyen_US
dc.subjectSports Injuriesen_US
dc.subjectMetabolismen_US
dc.subjectViabilityen_US
dc.subjectFrequencyen_US
dc.subjectPerfusionen_US
dc.subjectStrengthen_US
dc.title99mTc-sestamibi muscle scintigraphy to assess the response to neuromuscular electrical stimulation of normal quadriceps femoris muscleen_US
dc.typeArticleen_US

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