Do plasma leptin levels predict diastolic dysfunction in patients with hypertension?

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorTatli, Ersan
dc.contributor.authorAktoz, Meryem
dc.contributor.authorAltun, Armagan
dc.date.accessioned2024-06-12T11:07:37Z
dc.date.available2024-06-12T11:07:37Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Increased plasma leptin levels were showed in a number of cardiac problems such as hypertension, left ventricular hypertrophy, coronary artery disease and acute myocardial infarction. The possibility that leptin plays a role in the cardiovascular system was strengthened by the evidence that chronic leptin infusion had been shown to increase heart rate and blood pressure through stimulation of sympathetic nervous system activity. However, the relationship between increased plasma leptin levels and diastolic dysfunction hasn't been exactly investigated so far. Thus, we investigated relation between plasma leptin levels and diastolic dysfunction in patients with hypertension. Material and methods: Sixty mate patients with newly diagnosed essential hypertension were, consecutively included in the study. Hypertensive patients were divided into two groups according to Doppler echocardiographic parameters as patients with diastolic dysfunction (group 1, n = 38) and without diastolic dysfunction (group 11, n = 22). Both groups were compared patients' characteristics, plasma leptin levels, glucose, insulin, insulin resistance and thyroid hormones. Results: There were no significant differences between patients' characteristics, fasting insulin, glucose, insulin resistance, thyroid hormones. Echocardiographic evaluation showed similar values of septal and posterior wall thickness, left ventricular end-systolic and end-diastolic diameters, fractional shortening and ejection fraction in both groups. Plasma leptin levels were also found similarly in both groups (group 1, 40.6 +/- 18.4 ng/ml vs. group 1, 36.7 +/- 20.7 ng/ml, p = 0.650). Conclusions: We suggested that leptin levels didn't predict diastolic dysfunction in patients with hypertension.en_US
dc.identifier.endpage346en_US
dc.identifier.issn1734-1922
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-73449092501en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage342en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22108
dc.identifier.volume5en_US
dc.identifier.wosWOS:000271668400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectDiastolic Dysfunctionen_US
dc.subjectHypertensionen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectHeart-Failureen_US
dc.subjectHyperleptinemiaen_US
dc.subjectPressureen_US
dc.subjectGlucoseen_US
dc.titleDo plasma leptin levels predict diastolic dysfunction in patients with hypertension?en_US
dc.typeArticleen_US

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