Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

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dc.authoridNalcacioglu, Hulya/0000-0002-0686-9714
dc.authoridDoğan, Kenan/0000-0003-2191-1981
dc.authoridGIRISGEN, ILKNUR/0000-0003-2617-4466
dc.authoridYUKSEL, SELCUK/0000-0001-9415-1640
dc.authoridErfidan, Gokcen/0000-0001-5217-5847
dc.authoridKAYA, MEHTAP/0000-0002-6750-5172
dc.authoridyağmur, ismail/0000-0002-4208-5095
dc.authorwosidNalcacioglu, Hulya/L-1713-2016
dc.authorwosidDoğan, Kenan/JUF-6202-2023
dc.authorwosidGIRISGEN, ILKNUR/AAA-5113-2021
dc.authorwosidYUKSEL, SELCUK/C-5473-2015
dc.authorwosidYel, Sibel/D-5275-2018
dc.authorwosidErfidan, Gokcen/HHC-9443-2022
dc.authorwosidKAYA, MEHTAP/KHE-5340-2024
dc.contributor.authorDogan, Cagla Serpil
dc.contributor.authorTaner, Sevgin
dc.contributor.authorTiryaki, Betul Durucu
dc.contributor.authorAlaygut, Demet
dc.contributor.authorOzkayin, Nese
dc.contributor.authorKara, Aslihan
dc.contributor.authorGencler, Aylin
dc.date.accessioned2024-06-12T10:56:15Z
dc.date.available2024-06-12T10:56:15Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.en_US
dc.identifier.doi10.1007/s00467-023-06212-5
dc.identifier.endpage1519en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue5en_US
dc.identifier.pmid38040872en_US
dc.identifier.scopus2-s2.0-85178420777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1509en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-023-06212-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19728
dc.identifier.volume39en_US
dc.identifier.wosWOS:001112566400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChilden_US
dc.subjectMyelomeningoceleen_US
dc.subjectNeurogenic Bladderen_US
dc.subjectPredictorsen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectSpina-Bifidaen_US
dc.subjectNeurogenic Bladderen_US
dc.subjectRenal-Functionen_US
dc.subjectManagementen_US
dc.subjectAdolescentsen_US
dc.titleCharacteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort studyen_US
dc.typeArticleen_US

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