Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system

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dc.authoridOzyigit, F/0000-0002-0062-4281
dc.authoridozyigit, filiz/0000-0002-0062-4281
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGuray, Gurkan/0000-0003-1221-0841
dc.authorwosidOzyigit, F/HJY-5447-2023
dc.authorwosidozyigit, filiz/ABD-7066-2021
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidOZYİGİT, GULSEN/AAL-8830-2021
dc.contributor.authorUlugol, A
dc.contributor.authorDokmeci, D
dc.contributor.authorGuray, G
dc.contributor.authorSapolyo, N
dc.contributor.authorOzyigit, F
dc.contributor.authorTamer, M
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study was undertaken to determine the effects of intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) melatonin on mechanical allodynia and thermal hyperalgesia in mice with partial tight ligation of the sciatic nerve, and how the nitric oxide (NO) precursor L-arginine and the opiate antagonist naloxone influence this effect. A plantar analgesic meter was used to assess thermal hyperalgesia, and nerve injury-induced mechanical hyperalgesia was assessed with von Frey filaments. 1-5 weeks following the surgery, marked mechanical allodynia and thermal hyperalgesia developed in neuropathic mice. Intracerebroventricular and intraperitoneal melatonin, with its higher doses, produced a blockade of thermal hyperalgesia, but not mechanical allodynia. Administration of both L-arginine and naloxone, at doses which produced no effect on their own, partially reversed antihyperalgesic effect of melatonin. These results suggest that although it has different effects on neuropathic pain-related behaviors, melatonin may have clinical utility in neuropathic pain therapy in the future. It is also concluded that L-arginine-NO pathway and opioidergic system are involved in the antihyperalgesic effect of melatonin in nerve-injured mice. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.lfs.2005.07.002
dc.identifier.endpage1597en_US
dc.identifier.issn0024-3205
dc.identifier.issue14en_US
dc.identifier.pmid16107259en_US
dc.identifier.scopus2-s2.0-32944472282en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1592en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2005.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22697
dc.identifier.volume78en_US
dc.identifier.wosWOS:000235853100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectAllodyniaen_US
dc.subjectHyperalgesiaen_US
dc.subjectMelatoninen_US
dc.subjectInduced Tactile Allodyniaen_US
dc.subjectSciatic-Nerveen_US
dc.subjectMechanical Allodyniaen_US
dc.subjectThermal Hyperalgesiaen_US
dc.subjectBehavioral Signsen_US
dc.subjectPain Disordersen_US
dc.subjectPineal-Glanden_US
dc.subjectDorsal Hornen_US
dc.subjectRat Modelen_US
dc.subjectMouseen_US
dc.titleAntihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid systemen_US
dc.typeArticleen_US

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