Lipid profile, atherogenic indices, and their relationship with epicardial fat thickness and carotid intima-media thickness in celiac disease

Basit Öğe Kaydı
dc.authoridsayar, süleyman/0000-0001-7089-6082
dc.authoridKöstek, Osman/0000-0002-1901-5603
dc.authoridDOGANAY, H. LEVENT/0000-0002-2263-6689
dc.authoridCaklili, Ozge/0000-0001-7566-5427
dc.authorwosidsayar, süleyman/GPX-3309-2022
dc.authorwosidbaycan, omer faruk/GSI-6455-2022
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.authorwosidCaliskan, Mustafa/JYO-9455-2024
dc.authorwosidDOGANAY, H. LEVENT/ABI-1538-2020
dc.authorwosidCaklili, Ozge/AAT-7733-2020
dc.contributor.authorCaliskan, Zuhal
dc.contributor.authorDemircioglu, Kenan
dc.contributor.authorSayar, Suleyman
dc.contributor.authorKahraman, Resul
dc.contributor.authorCaklili, Ozge
dc.contributor.authorOzcan, Fatma Betul
dc.contributor.authorKostek, Osman
dc.date.accessioned2024-06-12T10:52:45Z
dc.date.available2024-06-12T10:52:45Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: In this study, we aimed to investigate the presence of subclinical atherosclerosis by measuring epicardial fat thickness (EFT) and carotid intima-media thickness (cIMT), evaluate low-level inflammation with high-sensitivity C-reactive protein (hsCRP), and evaluate whether there is a relationship among lipid profile, atherogenic indices, and hsCRP with these subclinical atherosclerosis markers in patients with celiac disease (CD). METHODS: After exclusion and inclusion criteria were applied, 31 patients with CD (24 female, mean age: 39.4 +/- 12.3 years) and 32 healthy controls (21 female, mean age: 39.5 +/- 4.4 years), totally 63 cases, were recruited. Subclinical atherosclerosis was evaluated with EFT by transthoracic echocardiography and cIMT by ultrasonography. Inflammatory markers including erythrocyte sedimentation rate (ESR), hsCRP, and lipid profile were recorded. Also, atherogenic indices were calculated: Castelli risk index I and II (TG/HDL-c and LDL-c/HDL-c, respectively), atherogenic index of plasma (AIP; logarithm TG/HDL-c), non-HDL-c (TG-HDL-c), and atherogenic coefficient (AC; non-HDL-c/HDL-c). RESULTS: EFT was significantly higher in the CD group (0.49 +/- 0.10 vs. 0.49 +/- 0.09; p-value: 0.02). Although cIMT was higher in the patient group, it did not reach statistical significance (0.51 +/- 0.08, 0.47 +/- 0.08; p-value: 0.10). HDL cholesterol level was found to be significantly lower (42.0 +/- 8.8 vs. 50.0 +/- 13.7; p-value: 0.01), and the plasma atherogenic index was found to be significantly higher in the patient group (0.98 +/- 0.50 vs. 0.62 +/- 0.64; p-value: 0.02). hsCRP (3.51 +/- 3.18 vs. 1.92 +/- 1.40; p-value: 0.02) and ESR (17.2 +/- 12.8 with 9.7 +/- 3.1; p-value: 0.01) were found to be significantly higher in the CD group. Although there was a significant positive correlation between EFT and hsCRP (r: 0.453; p-value: 0.01), there was a significant negative correlation between cIMT and HDL-cholesterol (-0.339; p-value: 0.05), and a significant positive correlation with the other components of the atherogenic index was found. CONCLUSION: The risk of atherosclerosis has been increased in patients with CD. Chronic inflammation may be responsible for this increase along with atherogenic indices.en_US
dc.identifier.doi10.14744/nci.2019.54936
dc.identifier.endpage247en_US
dc.identifier.issn2148-4902
dc.identifier.issue3en_US
dc.identifier.pmid31650110en_US
dc.identifier.startpage242en_US
dc.identifier.trdizinid337885en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2019.54936
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/337885
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18818
dc.identifier.volume6en_US
dc.identifier.wosWOS:000486393500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics Of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherogenic Dyslipidemiaen_US
dc.subjectCeliac Diseaseen_US
dc.subjectCimten_US
dc.subjectEpicardial Fat Thicknessen_US
dc.subjectT-Cellsen_US
dc.subjectAdipose-Tissueen_US
dc.subjectRisk-Factorsen_US
dc.subjectInflammationen_US
dc.subjectCholesterolen_US
dc.subjectGlutenen_US
dc.subjectAtherosclerosisen_US
dc.subjectAssociationen_US
dc.subjectAdultsen_US
dc.titleLipid profile, atherogenic indices, and their relationship with epicardial fat thickness and carotid intima-media thickness in celiac diseaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu