Low acylation stimulating protein levels are associated with cardiometabolic disorders-secondary to autoimmune activation?
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Soc Cardiology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: We investigated the possible association of serum acylation stimulating protein (ASP) with cardiometabolic disorders and the evidence of autoimmune activation. Methods: Population-based randomly selected 1024 participants were cross-sectionally and prospectively analyzed. ASP concentrations were measured with a validated ELISA kit. Correlations were sought separately in subjects with no cardiometabolic disorders (n=427) designated as healthy. Results: ASP was positively correlated with total testosterone and inversely correlated with platelet activating factor (PAF), PAF-acetylhydrolase (AH), in each gender, and positively correlated in healthy men with lipoprotein [Lp](a) and apolipoprotein B. Correlations of ASP with PAF values =22 nmol/L were abolished, contrasted to a strongly inverse one in subjects with PAF Conclusion: Findings can be explained by the notion of operation of immune responses against both ASP and oxidized PAF-like lipids of Lp(a) to yield for reduced values and increased likelihood of cardiometabolic disorders.
Açıklama
Anahtar Kelimeler
Acylation Stimulating Protein, Autoimmunity, Type-2 Diabetes, Lipoprotein(A), Metabolic Syndrome, Platelet Activating Factor, Phospholipids, Metabolic Syndrome, Phospholipase A(2), Complement C3, Disease, Lipids, Definition, Humans, Women, Risk
Kaynak
Anatolian Journal Of Cardiology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
17
Sayı
2
