Investigation of the relationship between MTRR A66G, MTR A2756G gene variations and cell anomalies in early diagnosis and progression of bladder cancer

Basit Öğe Kaydı
dc.authoridÇevik, Gökhan/0000-0001-5221-5132
dc.authoridKOROGLU, PINAR/0000-0002-3408-7867
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidÇevik, Gökhan/GZA-3993-2022
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.contributor.authorAydin, Pinar Koroglu
dc.contributor.authorCevik, Gokhan
dc.date.accessioned2024-06-12T10:54:47Z
dc.date.available2024-06-12T10:54:47Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The aim of this study is to investigate the relationship between MTRR A66G, MTRA2756G gene variations and cell anomalies in the early diagnosis and progression of bladder cancer. Methods PCR and RFLP methods were used to determine the genotype distributions of MTRR A66G and MTR A2756G gene variations. Peripheral smear preparations prepared from blood samples were fixed with methanol fixative and stained histochemically. Cellular morphological evaluations were made under the light microscope. Results In our study, AA-GG haplotype was observed significantly more in the patient group than control group (OR: 3.304, 95% CI: 1.023-10.665, p = 0.046). The significant increase was determined in terms of histological damage parameters in the patient group compared to the control group (p < 0.05). For multiple vacuoles damage parameter (mild score), AA genotype of MTR A2756G gene variation was significantly different compared to AA genotype of MTRR A66G gene variation (OR: 0.211, 0.049-0.912, p = 0.037). AA genotype of MTR A2756G gene variation was observed more than AA homozygous genotype of MTR A66G gene variation for giant platelets with different sizes damage parameter (mild score) (OR: 0.062, 0.017-0.228, p < 0.001). Conclusions In conclusion, in Thrace population, AA genotype of the MTR A2756G gene variation was significantly higher than the AA homozygous genotype of the MTR A66G gene variation as a genetic risk factor for the multiple vacuoles damage parameter. In addition, AA genotype of MTR A2756G gene variation was determined as a genetic risk factor for giant platelets with different sizes damage parameter.en_US
dc.identifier.doi10.1007/s11033-022-07597-6
dc.identifier.endpage7729en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue8en_US
dc.identifier.pmid35715601en_US
dc.identifier.scopus2-s2.0-85132399192en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7719en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-022-07597-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19178
dc.identifier.volume49en_US
dc.identifier.wosWOS:000812484300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Canceren_US
dc.subjectGenetic Variationen_US
dc.subjectPeripheral Smearen_US
dc.subjectHistological Damage Parametersen_US
dc.subjectPCR-RFLPen_US
dc.subjectMethionine-Synthase-Reductaseen_US
dc.subjectFolate Metabolismen_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.subjectAnemiaen_US
dc.subjectAssociationen_US
dc.subjectMeningiomaen_US
dc.subjectLeukemiaen_US
dc.subjectMthfren_US
dc.subjectSusceptibilityen_US
dc.titleInvestigation of the relationship between MTRR A66G, MTR A2756G gene variations and cell anomalies in early diagnosis and progression of bladder canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu