The pharmacological protection of renal function in patients undergoing cardiac surgery

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dc.contributor.authorNarin, Emine Bilge
dc.contributor.authorOztekin, Ilhan
dc.contributor.authorOztekin, SeherDeniz
dc.contributor.authorOgutmen, Betul
dc.date.accessioned2024-06-12T10:58:36Z
dc.date.available2024-06-12T10:58:36Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: To compare the effects of different routes and timings of administration of dopamine and mannitol used to alleviate the adverse effects of prolonged cardiopulmonary bypass (CPB) on renal functions in coronary artery surgery. Methods: Group I (n: 25 patients): Mannitol 1 g/kg was added into the priming solution for CPB. Group II (n: 25 patients): IV dopamine was administered at a dose of 2 mu g/kg/min during the time period between anesthesia induction and end of surgery. Group III (n: 25 patients): IV dopamine was administered at a dose of 2 mu g/kg/min during the time period between anesthesia induction and end of surgery and mannitol 1 g/kg was added into the priming solution for CPB. Group IV (n: 25 patients) (Controls): Furosemide was given when the urine output was low. Results: There was a significant increase in post operative urine microalbumin/creatinine ratio in all groups (p < 0.05), even increase of cystatin-c in Groups I, II and III (p < 0.01). Conclusions: We believe that concurrent use of dopamine infusion (2 mu g/kg/min) with mannitol (1 g/kg) during CPB may represent a more effective strategy for the prevention of the untoward effects of CPB on renal functions.en_US
dc.description.sponsorshipScientific Research and Project Development Unit of the DrSiyamiErsek Research and Training Hospital for Cardiovascular Surgeryen_US
dc.description.sponsorshipThis study was funded and supported by the Scientific Research and Project Development Unit of the DrSiyamiErsek Research and Training Hospital for Cardiovascular Surgery.en_US
dc.identifier.doi10.12669/pjms.315.7679
dc.identifier.endpage1061en_US
dc.identifier.issn1682-024X
dc.identifier.issue5en_US
dc.identifier.pmid26648986en_US
dc.identifier.scopus2-s2.0-84945261158en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://doi.org/10.12669/pjms.315.7679
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20126
dc.identifier.volume31en_US
dc.identifier.wosWOS:000365455900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary Artery Surgeryen_US
dc.subjectCystatin-Cen_US
dc.subjectDopamineen_US
dc.subjectMannitolen_US
dc.subjectMicroalbuminen_US
dc.subjectUrine Microalbumin/Creatinine Ratioen_US
dc.subjectSerum Cystatin-Cen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectRisk-Factorsen_US
dc.subjectFailureen_US
dc.subjectDysfunctionen_US
dc.subjectKidneyen_US
dc.titleThe pharmacological protection of renal function in patients undergoing cardiac surgeryen_US
dc.typeArticleen_US

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