Acetaminophen Mitigates Myocardial Injury Induced by Lower Extremity Ischemia-Reperfusion in Rat Model

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dc.authorwosidKubat, Emre/AAQ-3227-2021
dc.contributor.authorGeldi, Onur
dc.contributor.authorKubat, Emre
dc.contributor.authorUnal, Celal Selcuk
dc.contributor.authorCanbaz, Suat
dc.date.accessioned2024-06-12T10:52:14Z
dc.date.available2024-06-12T10:52:14Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The injury-reducing effect of acetaminophen, an effective analgesic and antipyretic on ischemia-reperfusion continues to attract great attention. This study analyzed the protective effect of acetaminophen on myocardial injury induced by ischemia-reperfusion in an experimental animal model from lower extremity ischemia-reperfusion. Methods: Twenty-four Sprague-Dawley female rats were randomized into three groups (n=8) as (i) control group (only laparotomy), (ii) aortic ischemia-reperfusion group (60 min of ischemia and 120 min of reperfusion) and (iii) ischemia-reperfusion + acetaminophen group (15 mg/kg/h intravenous acetaminophen infusion starting 15 minutes before the end of the ischemic period and lasting till the end of the reperfusion period). Sternotomy was performed in all groups at the end of the reperfusion period and the heart was removed for histopathological examination. The removed hearts were histopathologically investigated for myocytolysis, polymorphonuclear leukocyte (PMNL) infiltration, myofibrillar edema and focal hemorrhage. Results: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124). Conclusion: Acetaminophen is considered to have cardioprotective effect in rats, by reducing myocardial injury induced by abdominal aortic ischemia-reperfusion.en_US
dc.identifier.doi10.21470/1678-9741-2017-0218
dc.identifier.endpage264en_US
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue3en_US
dc.identifier.pmid30043918en_US
dc.identifier.scopus2-s2.0-85050459535en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.21470/1678-9741-2017-0218
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18640
dc.identifier.volume33en_US
dc.identifier.wosWOS:000441342700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasil Cirurgia Cardiovascen_US
dc.relation.ispartofBrazilian Journal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAorta, Abdominalen_US
dc.subjectAcetaminophenen_US
dc.subjectReperfusion Injuryen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectParacetamolen_US
dc.subjectMechanismsen_US
dc.subjectProtectsen_US
dc.titleAcetaminophen Mitigates Myocardial Injury Induced by Lower Extremity Ischemia-Reperfusion in Rat Modelen_US
dc.typeArticleen_US

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