Association of Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Coronary Artery Disease in Thrace Region of Turkey

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dc.authoridTAYLAN, GOKAY/0000-0002-7015-4537;
dc.authorwosidTAYLAN, GOKAY/HJZ-4693-2023
dc.authorwosidaksoy, yüksel/ABH-1304-2021
dc.authorwosidyilmaztepe, mustafa/AGE-8367-2022
dc.contributor.authorTaylan, Gokay
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorOzkalayci, Flora
dc.contributor.authorYilmaztepe, Mustafa Adem
dc.contributor.authorSivri, Nasir
dc.contributor.authorAksoy, Yuksel
dc.date.accessioned2024-06-12T10:50:13Z
dc.date.available2024-06-12T10:50:13Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Although the risk factors for coronary artery disease (CAD) are well established, a significant gap still exists in understanding the pathology of atherosclerotic heart disease evolving without conventional risk factors. Therefore, genetic factors are considered to play a significant role in this setting. The present study aimed to assess the relationship between angiotensin 2 type 1 receptor (AT1R) A1166C gene polymorphism and CAD. Materials and Methods: Patients with documented CAD (n=121) were compared with controls with normal coronary arteries (n=121). CAD was diagnosed using a coronary angiography. The median age of participants was 59 +/- 12 years with an equal sex distribution. A comparison between the two groups with regard to the AT1R A1166C gene polymorphism was made through the amplification of DNA using polymerase chain reaction. Results: This study demonstrated that adenine-adenine and cytosine-cytosine (CC) genotypes were more frequent, yet adenine-cytosine genotype was less frequent among patients with CAD compared with controls [p=0.003), 95% confidence interval (CI)]. The AT1R A1166C gene polymorphism along with the CC genotype and C allele was found to be associated with CAD. Further, gender, hypertension, family history, age, and low levels of serum high-density lipoprotein also had a significant relationship with AT1R A1166C gene polymorphism. Conclusion: The present study suggested AT1R A1166C gene polymorphism, CC genotype, and C allele as potential risk factors for atherosclerotic CAD. Patients harboring these genetic variants should be under close supervision for the development of CAD.en_US
dc.identifier.doi10.14744/etd.2020.90248
dc.identifier.endpage334en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue4en_US
dc.identifier.startpage329en_US
dc.identifier.trdizinid490541en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2020.90248
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/490541
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17918
dc.identifier.volume43en_US
dc.identifier.wosWOS:000672749700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectA1166Cen_US
dc.subjectAngiotensinen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectGene Polymorphismen_US
dc.subjectConverting-Enzymeen_US
dc.subjectSystemen_US
dc.subjectMetaanalysisen_US
dc.subjectRisken_US
dc.subjectHypertensionen_US
dc.subjectMassen_US
dc.titleAssociation of Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Coronary Artery Disease in Thrace Region of Turkeyen_US
dc.typeArticleen_US

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