Thickness changes in foveal, macular, and ganglion cell complex regions associated with Behcet uveitis during remission

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dc.authoridGüçlü, Hande/0000-0002-3021-0493;
dc.authorwosidGüçlü, Hande/AAW-9756-2020
dc.authorwosidOzal, Sadık Altan/B-5123-2019
dc.contributor.authorGurlu, Vuslat
dc.contributor.authorGuclu, Hande
dc.contributor.authorOzal, Altan
dc.date.accessioned2024-06-12T10:54:20Z
dc.date.available2024-06-12T10:54:20Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To investigate foveal, macular, and ganglion cell complex (GCC) thickness in patients with Behcet uveitis during remission. Methods: We included patients with panuveitis attacks caused by Behcet disease. Patients were taking immunosuppressive therapy and had no active ocular inflammation. After complete ophthalmologic examination, optical coherence tomography (OCT) was performed with a macula multi-cross protocol. The OCT images were evaluated for structural changes. Patients with no structural changes were imaged with the macula map protocol to obtain parafoveal and perifoveal macular and GCC thicknesses. Patients were compared to an age-matched control group with the Mann-Whitney U test. In correlation analyses, we examined relationships among visual acuity (logMAR), disease duration, and the number of attacks. Results: The study included 27 eyes of 21 patients (mean age 38.14 +/- 9.18 years; mean disease duration 65.4 +/- 74.6 months; mean number of attacks 2.5 +/- 1.9). The OCT showed foveal thicknesses of 260.29 +/- 34.17 mu m in patients and 280.58 +/- 19.54 mu m in controls (p = 0.010). Foveal thickness was not related to visual acuity (p = 0.485), but was negatively correlated to disease duration (p = 0.016) and number of attacks (p = 0.001). Patients and controls showed similar macular thickness in parafoveal quadrants (p = 0.294, p = 0.096, p = 0.88, p = 0.111) and perifoveal quadrants (p = 0.241, p = 0.517, p = 0.53288, p = 0.241). Patient parafoveal GCCs were significantly thinner than in controls in the inferior temporal quadrant (p = 0.041), but not in other quadrants (p = 0.867, p = 0.832, p = 0.390). Patient perifoveal GCCs were significantly thicker than in controls in the superior and inferior temporal quadrants (p = 0.008, p = 0.008) and somewhat thicker (but not significantly) in the superior and inferior nasal quadrants (p = 0.052, p = 0.138). Conclusions: Patients with Behcet uveitis in remission showed insignificant decreases in foveal and macular thickness and significant increases in perifoveal GCC thickness compared to controls. The increased perifoveal GCC thickness may result from macular ischemia persisting in remission.en_US
dc.identifier.doi10.5301/ejo.5000728
dc.identifier.endpage350en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue4en_US
dc.identifier.pmid26692057en_US
dc.identifier.scopus2-s2.0-84975113370en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.5301/ejo.5000728
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19003
dc.identifier.volume26en_US
dc.identifier.wosWOS:000382253200100en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Publishingen_US
dc.relation.ispartofEuropean Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet Diseaseen_US
dc.subjectGanglion Cell Complexen_US
dc.subjectMacular Ischemiaen_US
dc.subjectMacular Thicknessen_US
dc.subjectOptical Coherence Tomographyen_US
dc.subjectOptical Coherence Tomographyen_US
dc.subjectRetinal Artery-Occlusionen_US
dc.subjectVisual-Acuityen_US
dc.subjectDiseaseen_US
dc.subjectIschemiaen_US
dc.subjectDiagnosisen_US
dc.subjectLayersen_US
dc.titleThickness changes in foveal, macular, and ganglion cell complex regions associated with Behcet uveitis during remissionen_US
dc.typeArticleen_US

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