Evaluating trabecular microstructure of mandible and axis in osteoporosis, diabetes and chronic kidney disease using cone beam computed tomography

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dc.contributor.authorBilgili, Ersen
dc.contributor.authorUcok, Cemile Ozlem
dc.date.accessioned2024-06-12T11:08:08Z
dc.date.available2024-06-12T11:08:08Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives Like other bones, the mandible and cervical vertebrae are affected by several systemic diseases. The aim of this study is to evaluate the effects of osteoporosis (OP), diabetes mellitus (DM), and dialysis-indicated advanced chronic kidney disease (CKD), which are the most effective systemic diseases on the bone metabolism, on the trabecular microstructure of the mandible and cervical vertebrae using cone beam computed tomography (CBCT). Methods 81 patients who signed our informed consent form are involved in the study. 18 of them were diagnosed with osteoporosis, 18 of them with diabetes mellitus, 18 of the patients had dialysis-indicated CKD, and 27 of them were in the control group without any systemic diseases. Nine patients in the control group, patients with CKD and patients with DM were men, and nine were women. All patients with osteoporosis and 18 of the patients in the control group were women. Using CBCT images, microstructural parameters of trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp) and volume fraction (bone volume/total volume, BV/TV) were measured. Results Tb.Th and BV/TV values were higher in the control group, while Tb.Sp was higher in the osteoporosis group. The difference in BV/TV parameters was statistically significant (p = 0.02). In the DM group, Tb.Th and BV/TV values were lower and Tb.Sp values were significantly higher than in the control group (p = 0.001). In patients with advanced CKD, Tb.Th and BV/TV values were lower, while Tb.Sp values were higher than in the control group. Differences in Tb.Sp parameters were statistically significant (0.004). Conclusion Systemic diseases affect bone tissue at different levels, and to evaluate these effects, cortical and trabecular bone parts must be investigated separately, and findings must be combined with patients' clinical symptoms. CBCT is suitable for microstructural evaluation of trabecular bone and the mandible carries valuable data for this purpose.en_US
dc.identifier.doi10.1007/s11282-022-00603-4
dc.identifier.endpage92en_US
dc.identifier.issn0911-6028
dc.identifier.issn1613-9674
dc.identifier.issue1en_US
dc.identifier.pmid35355163en_US
dc.identifier.scopus2-s2.0-85127451084en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1007/s11282-022-00603-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22295
dc.identifier.volume39en_US
dc.identifier.wosWOS:000775733600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofOral Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMandibleen_US
dc.subjectVertebraen_US
dc.subjectTrabecular Boneen_US
dc.subjectOsteoporosisen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectKidney Diseasesen_US
dc.subjectBone-Mineral Densityen_US
dc.subjectFemoral-Necken_US
dc.titleEvaluating trabecular microstructure of mandible and axis in osteoporosis, diabetes and chronic kidney disease using cone beam computed tomographyen_US
dc.typeArticleen_US

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