The Relationship Between Virulence Factors of Helicobacter pylori and Severity of Gastritis in Infected Patients

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dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.authorwosidBukavaz, Sebnem/AAH-9346-2019
dc.authorwosidBukavaz, Sebnem/IYJ-6961-2023
dc.authorwosidBukavaz, Sebnem/AAA-2957-2020
dc.authorwosidUmit, Hasan/T-6236-2019
dc.contributor.authorUmit, Hasan
dc.contributor.authorTezel, Ahmet
dc.contributor.authorBukavaz, Sebnem
dc.contributor.authorUnsal, Gulbin
dc.contributor.authorOtkun, Muserref
dc.contributor.authorSoylu, Ali Riza
dc.contributor.authorTucer, Dilek
dc.date.accessioned2024-06-12T11:03:05Z
dc.date.available2024-06-12T11:03:05Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The best known genotypic virulence factors of H. pylori are cytotoxin-associated gene A (cagA) and vacuolating cytotoxin gene A (vacA). The objective of this study was to assess the relationship between H. pylori cagA and vacA status and histopathological findings. Esophagogastrodoedonoscopy was performed in 80 dyspeptic patients. Antrum and corpus biopsies were obtained for isolation of H. pylori and for histopathological assessment. The polymerase chain reaction was used to detect cagA and vacA genes of H. pylori using specific primers. Biopsy samples were stained with hematoxylin and eosin, and histopathological findings were graded using the updated Sydney system. H. pylori from 57 of the 80 patients was incubated. Of the 57 patients, 44 were cagA positive. In the corpus biopsy specimens there was a significant relationship between the density of H. pylori colonization (P = 0.02) and chronic inflammation (P = 0.02) and cagA-positive genotypes. In the antrum specimens there was a significant relationship between cagA positivity and neutrophil activity (P = 0.003) and glandular atrophy (P = 0.002), but not with H. pylori density, chronic inflammation, and intestinal metaplasia. The odds ratio of cagA-positive vs. cagA-negative strains for the presence of glandular atrophy, irrespective of grading and of gastric localization, was 4.62 (95% CI, 1.18-18.08, P = 0.041). No significant relationships were observed between vacA s1 and s2 genotypes and histopathological parameters. Corpus neutrophil infiltration was found to be more severe in the m1 group than in the m2 group (P = 0.004). Other histopathological features showed no difference between m1 and m2 genotypes. In conclusion H. pylori strains showing cagA positivity are associated with more severe gastritis in some histological features but virulence factors of H. pylori do not appear to determine the overall pattern of gastritis.en_US
dc.description.sponsorshipTrakya University Scientific Research Fund [TUBAP-594]; United European Gastroenterology Federation in the 13th UEGW, Copenhagen, Denmarken_US
dc.description.sponsorshipThis study was supported financially by the Trakya University Scientific Research Fund (TUBAP-594) and has received a grant from the United European Gastroenterology Federation in the 13th UEGW, Copenhagen, Denmark, 2005.en_US
dc.identifier.doi10.1007/s10620-008-0316-9
dc.identifier.endpage110en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue1en_US
dc.identifier.pmid18465229en_US
dc.identifier.scopus2-s2.0-58149299632en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-008-0316-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21520
dc.identifier.volume54en_US
dc.identifier.wosWOS:000261653400018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases And Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter Pylorien_US
dc.subjectGastritisen_US
dc.subjectBacterial Virulence Factorsen_US
dc.subjectCagaen_US
dc.subjectVacaen_US
dc.subjectPeptic-Ulcer Diseaseen_US
dc.subjectCaga Statusen_US
dc.subjectCytotoxin Productionen_US
dc.subjectTurkish Populationen_US
dc.subjectNonulcer Dyspepsiaen_US
dc.subjectConsensus Reporten_US
dc.subjectVaca Genotypesen_US
dc.subjectAssociationen_US
dc.subjectAntibodiesen_US
dc.subjectPathogenesisen_US
dc.titleThe Relationship Between Virulence Factors of Helicobacter pylori and Severity of Gastritis in Infected Patientsen_US
dc.typeArticleen_US

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