Involvement of Descending Serotonergic and Noradrenergic Systems and their Spinal Receptor Subtypes in the Antinociceptive Effect of Dipyrone

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124;
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.contributor.authorGencer, A.
dc.contributor.authorGunduz, O.
dc.contributor.authorUlugol, A.
dc.date.accessioned2024-06-12T10:52:02Z
dc.date.available2024-06-12T10:52:02Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe antinociceptive effect of dipyrone is partly due to its action upon pain-related central nervous system structures. Despite intensive research, the precise mechanisms mediating its analgesic effects remain unclear. Here, we aimed to determine whether neurotoxic destruction of descending inhibitory pathways affect dipyrone-induced antinociception and whether various spinal serotonergic and adrenergic receptors are involved in this antinociception. The nociceptive response was assessed by the tail-flick test. Mice injected with dipyrone (150, 300, 600 mg/kg, i. p.) elicited dose-related antinociception. The neurotoxins 5,7-dihydroxytryptamine (50 mu g/mouse) and 6-hydroxydopamine (20 mu g/mouse) are applied intrathecally to deplete serotonin and noradrenaline in the spinal cord. 3 days after neurotoxin injections, a significant reduction in the antinociceptive effect of dipyrone was observed. Intrathecal administration of monoaminergic antagonists (10 mu g/mouse), the 5-HT2a antagonist ketanserin, the 5-HT3 antagonist ondansetron, the 5-HT7 antagonist SB-258719, alpha(1)-adrenoceptor antagonist prazosin, alpha(2)-adrenoceptor antagonist yohimbine, and the beta-adrenoceptor antagonist propranolol also attenuated dipyrone antinociception. We propose that descending serotonergic and noradrenergic pathways play pivotal role in dipyrone-induced antinociception and spinal 5-HT2a, 5-HT3, and 5-HT7-serotonergic and alpha(1), alpha(2), and beta-adrenergic receptors mediate this effect.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2012/145]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2012/145).en_US
dc.identifier.doi10.1055/s-0034-1398550
dc.identifier.endpage649en_US
dc.identifier.issn2194-9379
dc.identifier.issn2194-9387
dc.identifier.issue12en_US
dc.identifier.pmid25647230en_US
dc.identifier.scopus2-s2.0-84948063772en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage645en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1398550
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18575
dc.identifier.volume65en_US
dc.identifier.wosWOS:000367809900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofDrug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntinociceptionen_US
dc.subjectDescending Inhibitionen_US
dc.subjectDipyroneen_US
dc.subjectNoradrenergic Systemen_US
dc.subjectSerotonergic Systemen_US
dc.subjectEndogenous Opioidsen_US
dc.subjectRatsen_US
dc.subjectMetamizolen_US
dc.subjectMiceen_US
dc.subjectAcetaminophenen_US
dc.subjectActivationen_US
dc.subjectPathwaysen_US
dc.subjectAgonistsen_US
dc.subjectNeuronsen_US
dc.subject5,7-Dihydroxytryptamineen_US
dc.titleInvolvement of Descending Serotonergic and Noradrenergic Systems and their Spinal Receptor Subtypes in the Antinociceptive Effect of Dipyroneen_US
dc.typeArticleen_US

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