The serum amino acid profile in COVID-19

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dc.authoridCelik, Saffet/0000-0002-4225-2471
dc.authoridYaman, Mehmet Emrah/0000-0002-8406-7653
dc.authoridAKMAN, Tugrul Cagri/0000-0002-5439-950X
dc.authorwosidCelik, Saffet/R-9630-2017
dc.authorwosidBayrak, Burak/AAE-4163-2021
dc.authorwosidYaman, Mehmet Emrah/AFX-8006-2022
dc.authorwosidhalici, zekai/HKN-9826-2023
dc.contributor.authorAtila, Alptug
dc.contributor.authorAlay, Handan
dc.contributor.authorYaman, Mehmet Emrah
dc.contributor.authorAkman, Tugrul Cagri
dc.contributor.authorCadirci, Elif
dc.contributor.authorBayrak, Burak
dc.contributor.authorCelik, Saffet
dc.date.accessioned2024-06-12T10:51:25Z
dc.date.available2024-06-12T10:51:25Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe pandemic of the coronavirus disease (COVID-19) caused by SARS-CoV-2 affects millions of people worldwide. There are still many unknown aspects to this infection which affects the whole world. In addition, the potential impacts caused by this infection are still unclear. Amino acid metabolism, in particular, contains significant clues in terms of the development and prevention of many diseases. Therefore, this study aimed to compare amino acid profile of COVID-19 and healthy subject. In this study, the amino acid profiles of patients with asymptomatic, mild, moderate, and severe/critical SARS-CoV-2 infection were scanned with LC-MS/MS. The amino acid profile encompassing 30 amino acids in 142 people including 30 control and 112 COVID-19 patients was examined. 20 amino acids showed significant differences when compared to the control group in COVID-19 patient groups with different levels of severity in the statistical analyses conducted. It was detected that the branched-chain amino acids (BCAAs) changed in correlation with one another, and l-2-aminobutyric acid and l-phenylalanine had biomarker potential for COVID-19. Moreover, it was concluded that l-2-aminobutyric acid could provide prognostic information about the course of the disease. We believe that a new viewpoint will develop regarding the diagnosis, treatment, and prognosis as a result of the evaluation of the serum amino acid profiles of COVID-19 patients. Determining l-phenylalanine and l-2-aminobutyric levels can be used in laboratories as a COVID-19-biomarker. Also, supplementing COVID patients with taurine and BCAAs can be beneficial for treatment protocols.en_US
dc.identifier.doi10.1007/s00726-021-03081-w
dc.identifier.endpage1588en_US
dc.identifier.issn0939-4451
dc.identifier.issn1438-2199
dc.identifier.issue10en_US
dc.identifier.pmid34605988en_US
dc.identifier.scopus2-s2.0-85116388630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1569en_US
dc.identifier.urihttps://doi.org/10.1007/s00726-021-03081-w
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18363
dc.identifier.volume53en_US
dc.identifier.wosWOS:000703524500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofAmino Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmino Aciden_US
dc.subjectCOVID-19en_US
dc.subjectBcaasen_US
dc.subjectL-2-Aminobutyric Aciden_US
dc.subjectL-Phenylalanineen_US
dc.subjectTaurineen_US
dc.subjectGlutamine-Metabolismen_US
dc.subjectArginineen_US
dc.subjectProlineen_US
dc.subjectLymphocytesen_US
dc.subjectSplenocytesen_US
dc.subjectMacrophagesen_US
dc.subjectCitrullineen_US
dc.subjectHybridomaen_US
dc.subjectGlucoseen_US
dc.subjectEventsen_US
dc.titleThe serum amino acid profile in COVID-19en_US
dc.typeArticleen_US

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