Involvement of serotonergic system in cannabinoid analgesia
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer New York
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Plant cannabinoids have been used historically as a therapeutic agent in some folk medicine for the treatment of headache, fibromyalgia, and irritable bowel and related conditions in which serotonergic pathways are considered to play a crucial role in pathogenesis and treatment modalities. Serotonergic system has important modulatory role in acute and chronic pain conditions. The analgesic efficacy of cannabinoids in acute and chronic pain appear to be mediated, at least in part, through the regulation of the serotonergic system. In this chapter, we review the interaction between cannabinoids and serotonergic system in the peripheral, spinal and supraspinal sites with special emphasis on serotonin in central sites by which cannabinoid CB1 receptor activation reinforce descending serotonergic pathways to produce antinociceptive effects. © 2013 Springer Science+Business Media New York. All rights are reserved.
Açıklama
Anahtar Kelimeler
5-Ht; Cannabinoid Analgesia; Cb1 Agonists; Cb2 Agonists; Serotonergic Neuromodulation; Serotonergic System
Kaynak
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
WoS Q Değeri
Scopus Q Değeri
N/A
