The IL-33 gene is related to increased susceptibility to systemic sclerosis

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dc.authoridALIBAZ-ONER, FATMA/0000-0002-6653-1758;
dc.authorwosidDireskeneli, Haner/AAS-5508-2020
dc.authorwosidALIBAZ-ONER, FATMA/AAR-2072-2020
dc.authorwosidpehlivan, yavuz/AAG-8227-2021
dc.contributor.authorKoca, Suleyman Serdar
dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorKara, Murat
dc.contributor.authorAlibaz-Oner, Fatma
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorYilmaz, Neslihan
dc.contributor.authorCetin, Gozde Yildirim
dc.date.accessioned2024-06-12T11:15:57Z
dc.date.available2024-06-12T11:15:57Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSystemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc.en_US
dc.identifier.doi10.1007/s00296-015-3417-8
dc.identifier.endpage584en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue4en_US
dc.identifier.pmid26743213en_US
dc.identifier.scopus2-s2.0-84953372296en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-015-3417-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24140
dc.identifier.volume36en_US
dc.identifier.wosWOS:000374567100016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectGeneticen_US
dc.subjectIL-33 Gene Polymorphismen_US
dc.subjectHuman Th2 Cellsen_US
dc.subjectDiseaseen_US
dc.subjectSt2en_US
dc.subjectAssociationen_US
dc.subjectSclerodermaen_US
dc.subjectFibrosisen_US
dc.subjectInterleukin-4en_US
dc.subjectPolymorphismsen_US
dc.subjectInvolvementen_US
dc.subjectCytokineen_US
dc.titleThe IL-33 gene is related to increased susceptibility to systemic sclerosisen_US
dc.typeArticleen_US

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