Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administration

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:59:38Z
dc.date.available2024-06-12T10:59:38Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe cannabinoid system has been suspected to play a role in the mechanisms of action of dipyrone and paracetamol. Our purpose was to measure the local endocannabinoid and N-acylethanolamide levels in the brain and spinal cord of rats following dipyrone and paracetamol administration. Nociception was assessed 1, 5, and 12 h following drug injections in Wistar rats, using tail-flick and hot-plate tests. The antinociceptive effects of dipyrone (150, 300, and 600 mg/kg, i.p.) and paracetamol (30, 100, and 300 mg/kg, i.p.) were observed. After administration of the highest doses of dipyrone and paracetamol, endocannabinoid (N-arachidonoylethanolamide (AEA), 2-arachidonoylglycerol (2-AG)) and N-acylethanolamide (palmitoylethanolamide (PEA), oleoylethanolamide (OEA)) levels were measured in the periaqueductal gray (PAG), rostral ventromedial medulla (RVM), and spinal cords of rats using tandem mass spectrometry with liquid chromatography. Increased 2-AG levels were observed in the PAG and the RVM 12 h after paracetamol injection; dipyrone exerted no action on 2-AG levels. Analgesic administrations led to a reduction in AEA levels in the RVM and spinal cord; similar decreases in PEA and OEA levels were observed in the RVM and the spinal cord. Dipyrone and paracetamol administrations appear to exert complicated effects on endocannabinoid and N-acylethanolamide levels in rats.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2018/14]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2018/14). We thank K. Duvan-Aydemir for her technical support for behavioral analysis, and TUTAGEM for performing LC-MS/MS analysis. This project will be presented as a poster in 11th Congress of the European Pain Federation EFIC, held in Valencia, Spain, on 4-7 September 2019.en_US
dc.identifier.doi10.1139/cjpp-2019-0015
dc.identifier.endpage1041en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue11en_US
dc.identifier.pmid31283890en_US
dc.identifier.scopus2-s2.0-85074184600en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2019-0015
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20517
dc.identifier.volume97en_US
dc.identifier.wosWOS:000494261600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal Of Physiology And Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDipyroneen_US
dc.subjectEndocannabinoiden_US
dc.subjectN-Acylethanolamideen_US
dc.subjectParacetamolen_US
dc.subjectCannabinoid Cb1 Receptorsen_US
dc.subjectInvolvementen_US
dc.subjectPainen_US
dc.subjectInflammationen_US
dc.subjectMetamizolen_US
dc.subjectBlockadeen_US
dc.subjectAgonisten_US
dc.subjectMetabolitesen_US
dc.subjectInhibitorsen_US
dc.subjectToleranceen_US
dc.titleEndocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administrationen_US
dc.typeArticleen_US

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