Prognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapy

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dc.contributor.authorHarmankaya, Ilknur
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorTastekin, Ebru
dc.contributor.authorTurkkau, Gorkem
dc.contributor.authorCaloglu, Murat
dc.contributor.authorUzal, Cem
dc.date.accessioned2024-06-12T11:08:32Z
dc.date.available2024-06-12T11:08:32Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Aims: We aimed to investigate the prognostic importance of the microvessel density (MVD) value, the vascular endothelial growth factor (VEGF) expression, and the presence of perineural invasion (PNI) in laryngeal cancer (LSCC) patients. Methods: Pathological specimens of 62 LSCC patients were assessed for the evaluation of the MVD value, the VEGF expression level, and the presence of PNI of the tumors. The tumor characteristics and prognostic effects of these parameters on local control (LC) and overall survival (OS) were analyzed. Statistical Analysis: Descriptive analyses were done using frequencies for the demographic variables. The survival estimates were calculated by the Kaplan-Meier survival curves. The effects of the parameters on LC and OS were investigated by using the log-rank test comparing the survival rates. Cox regression analysis was used for multivariable analysis. Results: The 5-year LC and OS rates of the 62 LSCC patients were 64.5 and 53.9%, respectively. Twenty-two patients (35.5%) had PNI and the frequency of PNI was higher in the patients with a high-grade disease (P = 0.01). The MVD value was higher in the tumors of older patients (P = 0.035) and was correlated with the VEGF expression (P = 0.009). A higher tumor grade was related to a higher VEGF expression (P = 0.01) and the increase in the VEGF expression was associated with a significant decrease in the OS (P = 0.03). Conclusion: The VEGF expression, the MVD value, and the presence of PNI had no prognostic significance on the LC in the LSCC patients while only the VEGF expression was associated with the OS.en_US
dc.identifier.doi10.4103/ijpm.ijpm_655_21
dc.identifier.endpage526en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue3en_US
dc.identifier.pmid35900477en_US
dc.identifier.scopus2-s2.0-85135379356en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.4103/ijpm.ijpm_655_21
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22473
dc.identifier.volume65en_US
dc.identifier.wosWOS:000935829800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Pathology And Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrovessel Densityen_US
dc.subjectPerineural Invasionen_US
dc.subjectVascular Endothelial Growth Factor Expressionen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectSquamous-Cell Carcinomaen_US
dc.subjectTumor Angiogenesisen_US
dc.subjectHeaden_US
dc.subjectPredictsen_US
dc.titlePrognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapyen_US
dc.typeArticleen_US

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