CT visual quantitative evaluation of hypertensive patients with coronavirus disease (COVID-19): Potential influence of angiotensin converting enzyme inhibitors / angiotensin receptor blockers on severity of lung involvement

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dc.authoridAkkaya Isik, Sinem/0000-0001-9941-2993
dc.authoridSaylan, Bengu/0000-0002-5922-0847
dc.authoridYesildal, Melike/0000-0003-4341-6076
dc.authorwosidAkkaya Isik, Sinem/JLM-2026-2023
dc.contributor.authorSamanci, Cesur
dc.contributor.authorSaylan, Bengu
dc.contributor.authorGulsen, Gokce
dc.contributor.authorAkkaya, Yuksel
dc.contributor.authorYesildal, Melike
dc.contributor.authorIsik, Sinem Akkaya
dc.contributor.authorUstabasioglu, Fethi Emre
dc.date.accessioned2024-06-12T10:58:37Z
dc.date.available2024-06-12T10:58:37Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective There is not enough data on the effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on lung involvement in patients with COVID-19 pneumonia and hypertension (HT). Our aim was to compare the lung involvement of the HT patients hospitalized for COVID-19 using ACEIs/ARBs with the patients taking other anti-HT medications. Methods : Patients who have a diagnosis of HT among the patients treated for laboratory-confirmed COVID-19 between 31 March 2020 and 28 May 2020 were included in the study. One hundred and twenty-four patients were divided into two as ACEIs/ARBs group (n = 75) and non-ACEIs/ARBs group (n = 49) according to the anti-HT drug used. The chest CT involvement areas of these two groups were evaluated quantitatively by two observers including all lobes, and total severity score (TSS) was calculated. These TSS values were compared between drug groups and clinical groups Results In clinical classification; there were 4 (%3.2) asymptomatic, 5 (4.0%) mild type, 92 (74.1%) common type, 14 (11.3%) severe type, 9 (7.3%) critical type patients. ACEI/ARB group's TSS (mean +/- SD, 7.74 +/- 3.54) was statistically higher than other anti-HT medication group (mean +/- SD, 4.40 +/- 1.89) (p < .001). Likewise, severe-critical clinical type's TSS (mean +/- SD, 9.17 +/- 3.44) was statistically higher than common type (mean +/- SD, 5.76 +/- 3.07) (p < .001). Excellent agreement was established between the two blinded observers in the TSS measurements. Conclusions Quantitative evaluation of CT and TSS score can give an idea about the clinical classification of the patient. TSS is higher in ACEI/ARB group than non-ACEIs/ARBs group.en_US
dc.identifier.doi10.1080/10641963.2021.1883051
dc.identifier.endpage348en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue4en_US
dc.identifier.pmid33583283en_US
dc.identifier.scopus2-s2.0-85100844769en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1080/10641963.2021.1883051
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20135
dc.identifier.volume43en_US
dc.identifier.wosWOS:000617976000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical And Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronavirus Diseaseen_US
dc.subjectCovid-19en_US
dc.subjectComputed Tomographyen_US
dc.subjectPneumoniaen_US
dc.titleCT visual quantitative evaluation of hypertensive patients with coronavirus disease (COVID-19): Potential influence of angiotensin converting enzyme inhibitors / angiotensin receptor blockers on severity of lung involvementen_US
dc.typeArticleen_US

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