An epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010*

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dc.contributor.authorTurgut, Nilda
dc.contributor.authorSaracoglu, Gamze Varol
dc.contributor.authorKat, Selahattin
dc.contributor.authorBalci, Kemal
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorBirgili, Ozlem
dc.contributor.authorKabayel, Levent
dc.date.accessioned2024-06-12T10:51:35Z
dc.date.available2024-06-12T10:51:35Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to investigate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Thrace, Turkey in a five-year time period (2006-2010). Methods: Study population included residents of three provinces (Edirne, Tekirdag, Kirklareli) in the Thrace region. Cases were ascertained from all of the neurologic centers and hospitals of these provinces. Demographic and clinical information was collected for each patient. Newly diagnosed ALS patients who are fulfilling the El Escorial revised diagnostic criteria were enrolled into the study. Results: We identified a total of 145 patients (93 males, 52 females). The mean age at diagnosis was 57.0 +/- 13.6. According to El Escorial criteria, 60.0% of the cases were definite ALS, 24.8% were probable, and 15.2% were possible ALS. Thirty-two cases were bulbar (22.1%), 113 cases (77.9%) were spinal onset. Mean time delay from onset to diagnosis was 12.0 +/- 11.2 months. Age-gender standardized incidence rates with reference to Turkey, USA 2008 census were 1.9 (95% confidence interval (CI), 1.8-2.1), 1.9 (95%CI, 1.8-2.2) for overall. There were 112 living ALS patients at the end of the study. Crude point prevalence was calculated as 7.3 per 100,000 population (95%CI, 5.9-8.7). Conclusions: This is the first study to provide fundamental data about demographic and clinical characteristics about ALS in Thrace region of Turkey. Incidence and prevalence of ALS in Thrace region of Turkey appear to be comparable with European countries.en_US
dc.identifier.doi10.1080/21678421.2018.1525403
dc.identifier.endpage106en_US
dc.identifier.issn2167-8421
dc.identifier.issn2167-9223
dc.identifier.issue1-2en_US
dc.identifier.pmid30468083en_US
dc.identifier.scopus2-s2.0-85057345513en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1080/21678421.2018.1525403
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18392
dc.identifier.volume20en_US
dc.identifier.wosWOS:000467740300013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofAmyotrophic Lateral Sclerosis And Frontotemporal Degenerationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmyotrophic Lateral Sclerosisen_US
dc.subjectEpidemiologyen_US
dc.subjectIncidenceen_US
dc.subjectPrevalenceen_US
dc.subjectMotor-Neuron Diseaseen_US
dc.subjectAlsen_US
dc.subjectPopulationen_US
dc.subjectSusceptibilityen_US
dc.subjectDiagnosisen_US
dc.subjectSurvivalen_US
dc.subjectEnglanden_US
dc.titleAn epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010*en_US
dc.typeArticleen_US

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