Effect of L-carnitine on serum paraoxonase, arylesterase and lactonase activities and oxidative status in experimental colitis

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorOzgun, Eray
dc.contributor.authorOzgun, Gulben Sayilan
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorYalcin, Omer
dc.contributor.authorGokmen, Selma Suer
dc.date.accessioned2024-06-12T11:01:36Z
dc.date.available2024-06-12T11:01:36Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Oxidative stress plays an important role in the pathogenesis of inflammatory bowel disease. We investigated antioxidant L-carnitine effect on activities of paraoxonase 1 enzyme which is also synthesized in colon and oxidative status in experimental colitis. Material and Methods: Wistar albino female rats were divided into four groups randomly: control, colitis, pre-treatment and treatment groups. To induce colitis, single dose of 1 mL acetic acid (%4) was given intrarectally to colitis, pre-treatment and treatment groups. Single dose of 500 mg/kg L-carnitine was given intraperitoneally 1 hour before inducing colitis to pre-treatment group and 24 hours after inducing colitis to treatment group. All groups were sacrificied 48 hours after intrarectally administration. Existence of colitis was confirmed by histopathological changes. Paraoxonase, arylesterase and lactonase activities, total oxidant and antioxidant status, malondialdehyde, and total sialic acid were measured in serum. Oxidative stress index was calculated from the formula. Results: While serum malondialdehyde, total sialic acid, total oxidant status and oxidative stress index were significantly elevated, serum paraoxonase, arylesterase and lactonase activities and total antioxidant status were significantly decreased in acetic-acid induced experimental colitis. In acetic-acid induced experimental colitis, L-carnitine caused a significant decrease in serum malondialdehyde, total sialic acid, total oxidant status and oxidative stress index but a significant increase in serum arylesterase and lactonase activities of treatment group only. Conclusion: L-Carnitine has an increasing effect on serum arylesterase and lactonase activities and decreasing effect on oxidative stress in acetic acid-induced experimental colitis. Therefore, L-carnitine may be useful for the treatment of inflammatory bowel disease.en_US
dc.identifier.doi10.5505/tjb.2013.29292
dc.identifier.endpage153en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84879991597en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2013.29292
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20964
dc.identifier.volume38en_US
dc.identifier.wosWOS:000323181600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Colitisen_US
dc.subjectL-Carnitineen_US
dc.subjectParaoxonaseen_US
dc.subjectArylesteraseen_US
dc.subjectLactonaseen_US
dc.subjectOxidative Stressen_US
dc.subjectMalondialdehydeen_US
dc.subjectTotal Sialic Aciden_US
dc.subjectSialic-Aciden_US
dc.subjectMalondialdehyde Levelsen_US
dc.subjectStressen_US
dc.subjectPon1en_US
dc.subjectInflammationen_US
dc.subjectDiseaseen_US
dc.subjectProteinen_US
dc.subjectModelen_US
dc.subjectAssayen_US
dc.titleEffect of L-carnitine on serum paraoxonase, arylesterase and lactonase activities and oxidative status in experimental colitisen_US
dc.typeArticleen_US

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