Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authoridSalihoglu, Yavuz Sami/0000-0003-2465-9128
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidAktas, Ranan/F-2910-2016
dc.contributor.authorDurmus-Altun, G
dc.contributor.authorAltun, A
dc.contributor.authorAktas, RG
dc.contributor.authorSalihoglu, YS
dc.contributor.authorYigitbasi, NO
dc.date.accessioned2024-06-12T10:51:26Z
dc.date.available2024-06-12T10:51:26Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe purpose of the study was; (i) to deter-mine whether I-123-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with Tc-99m-DTPA radioacrosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent I-123-MIBG and Tc-99m-DTPA radioaerosol scintigraphy at the end of the treatment period. I-123-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after 'intravenous injection of the radiopharmaccutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of I-123-MIBG were determined. Two days after I-123-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. I-123-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T-1/(2) values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5,p = 0.02). I-123-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, Tc-99m-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.en_US
dc.identifier.doi10.1007/BF02984608
dc.identifier.endpage224en_US
dc.identifier.issn0914-7187
dc.identifier.issue3en_US
dc.identifier.pmid15981675en_US
dc.identifier.scopus2-s2.0-21044434811en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1007/BF02984608
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18368
dc.identifier.volume19en_US
dc.identifier.wosWOS:000229687800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Society Nuclear Medicineen_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmiodaroneen_US
dc.subjectPulmonary Toxicityen_US
dc.subjectI-123-MIBGen_US
dc.subjectTc-99m-DTPA Radioaerosolen_US
dc.subjectScintigraphyen_US
dc.subjectLung Scintigraphyen_US
dc.subjectAerosolen_US
dc.subjectPermeabilityen_US
dc.subjectClearanceen_US
dc.subjectDiseaseen_US
dc.subjectExtractionen_US
dc.subjectRetentionen_US
dc.subjectMarkeren_US
dc.subjectInjuryen_US
dc.titleUse of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphyen_US
dc.typeArticleen_US

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