Clinicopathological Characteristics and Prognosis of Patients According To Recurrence Time After Radical Nephrectomy for Localized Renal Cell Carcinoma: A Multicenter Study of Anatolian Society of Medical Oncology (ASMO)

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dc.authoridÖksüzoğlu Çakmak, Ömür Berna/0000-0002-2756-8646
dc.authoridUlas, Arife/0000-0003-2918-2592
dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridDEMIRCI, UMUT/0000-0002-4833-6721
dc.authorwosidDurnalı, Ayşe/AAZ-8847-2021
dc.authorwosidDurnalı, Ayşe/ABC-2229-2021
dc.authorwosidÖksüzoğlu Çakmak, Ömür Berna/HKN-6428-2023
dc.authorwosidKucukoner, Mehmet/E-1162-2013
dc.authorwosidUlas, Arife/HGD-4686-2022
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.authorwosidAYDIN, Kubra/ABG-5437-2022
dc.contributor.authorBozkurt, Oktay
dc.contributor.authorInanc, Mevlude
dc.contributor.authorHacibekiroglu, Ilhan
dc.contributor.authorEsbah, Onur
dc.contributor.authorSeker, Metin
dc.contributor.authorUlas, Arife
dc.contributor.authorAydin, Kubra
dc.date.accessioned2024-06-12T11:12:44Z
dc.date.available2024-06-12T11:12:44Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: We investigated the clinicopathological features in patients with recurrent RCC within 5 years or more than 5 years after nephrectomy and determined predictors of survival and response treatment after recurrence. Materials and Methods: We retrospectively evaluated 144 patients with disease recurrence; 73 had recurrence more than 5 years after radical nephrectomy. We compared clinicopathological characteristics in patients with disease recurrence before vs. after 5 years. In addition, we investigated predictors of survival and response to treatment after recurrence. Results: Seventy-one patients (49%) were diagnosed with recurrence within 5 years after radical nephrectomy (early recurrence) and 73 patients (51%) were diagnosed with recurrence more than 5 years after radical nephrectomy (late recurrence). Fuhrman grade, tumor necrosis and lymphovascular invasion were statistically significantly different between the two groups (p<0.001, p=0.013, p=0.026, respectively). The late recurrence patients were significantly associated with the Memorial Sloan Kettering Cancer Center (MSKCC) favorable risk group compared to patients with early recurrence (p=0.001). From the time of disease recurrence, median Overall Survival (OS) was 36.0 (95% Confidence Interval (CI) 30.7-412) months in the late recurrence group, and 19 (95% CI 15.4-22.5) months in the early recurrence group (p=0.01). The median Progression Free Survival (PFS) was 6 (95% CI 3.87-8.12) months in the early recurrence group, and 18 (95% CI 15.4-20.5) months for the late recurrence group (p<0.001). Conclusion: Early recurrence was significantly associated with Fuhrman grade 3-4, tumor necrosis, lymphovascular invasion, MSKCC poor- risk group compared to patients with late recurrence. The study also demonstrated a potential prognostic value of late recurrence in terms of PFS and OS.en_US
dc.identifier.endpage4470en_US
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.issue8en_US
dc.identifier.pmid25075086en_US
dc.identifier.scopus2-s2.0-84908676244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4463en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23288
dc.identifier.volume34en_US
dc.identifier.wosWOS:000339773400080en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofAnticancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPredictive And Prognostic Factorsen_US
dc.subjectLate Recurrenceen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectInterferon-Alphaen_US
dc.subjectSurvivalen_US
dc.subjectValidationen_US
dc.subjectDiseaseen_US
dc.subjectModelen_US
dc.subjectScoreen_US
dc.subjectRisken_US
dc.subjectProgressionen_US
dc.subjectGuidelinesen_US
dc.subjectFeaturesen_US
dc.titleClinicopathological Characteristics and Prognosis of Patients According To Recurrence Time After Radical Nephrectomy for Localized Renal Cell Carcinoma: A Multicenter Study of Anatolian Society of Medical Oncology (ASMO)en_US
dc.typeArticleen_US

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