Association between beta-sympathomimetic tocolysis and risk of autistic spectrum disorders, behavioural and developmental outcome in toddlers
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Open Access Macedonian Journal of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM: To investigate whether maternal intravenous beta-mimetic tocolytic therapy increases the risk of autistic spectrum disorders (ASD) and poorer behavioural and developmental outcomes. METHOD: Our study is a prospective case-control study among 90 children between 1.5 and three years old. Cases (n = 46) were toddlers with betamimetic tocolytic exposure; control group toddlers (n = 44) were tocolytic untreated. Treated and untreated groups were also divided into subgroups: term and preterm delivered. The gestational age of tocolytic treatment start, the dose and duration of exposure in hours were obtained from obstetric medical records. The Brief Infant-Toddler Social and Emotional Assessment (BITSEA), the Modified Checklist for Autism in Toddlers (M-CHAT) and the Denver Developmental Screening Test (DDST) tests were applied for evaluation of social, emotional problems, autism and developmental disorders. RESULTS: Term and preterm born toddlers treated tocolytically in utero didn’t demonstrate a higher risk of autistic disorders or poorer behavioural and developmental results than controls. In the preterm group, the earliest start of tocolytic treatment was correlated with toddlers lower score of the Competencies Scale (p = 0.009) and a higher score of the Problems Scale (p = 0.048). Also, we concluded that preterm membrane rupture was associated with higher ASD risk in the untreated group (p = 0.043). CONCLUSION: Exposure to betamimetics during pregnancy was not associated with an increased risk of autism, behavioural and developmental disorders. © 2017 Mengühan Araz Altay, Işık Görker, Rakhshanda Aslanova, Leyla Bozatlı, Nesrin Turan, Petek Balkanlı Kaplan .
Açıklama
Anahtar Kelimeler
Autism Spectrum Disorder; Behavioural And Developmental Disorders; Beta-Mimetics; Tocolysis, Beta Adrenergic Receptor Stimulating Agent; Apgar Score; Article; Autism; Behavior; Birth Weight; Body Height; Brief Infant Toddler Social And Emotional Assessment; Case Control Study; Child; Clinical Article; Clinical Outcome; Cohort Analysis; Controlled Study; Denver Developmental Screening Test; Disease Association; Education; Emotion Assessment; Environmental Factor; Female; Head Circumference; Human; Kindergarten; Male; Maternal Age; Maternal Deprivation; Mental Disease Assessment; Mental Health; Modified Checklist For Autism In Toddlers; Pregnancy; Premature Fetus Membrane Rupture; Preschool Child; Prospective Study; Psychomotor Development; Psychomotor Performance; Risk; Television Viewing; Tocolysis; Toddler
Kaynak
Open Access Macedonian Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
5
Sayı
6
