Influence of N-acetylcysteine on renal toxicity of cadmium in rats

Basit Öğe Kaydı
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorAtakan, Irfan H.
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorOzpuyan, Fulya
dc.contributor.authorSeren, Guelay
dc.contributor.authorTokuc, Burcu
dc.date.accessioned2024-06-12T10:52:04Z
dc.date.available2024-06-12T10:52:04Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the ability of N-acetylcysteine (NAC) to prevent cadmium (Cd)-induced renal damage and whether NAC would reverse cadmium damage to the kidney. Fifty adult male rats were divided into five experimental groups: group 1 received tap water for 3 months and 7 days, group 2 received cadmium chloride (CdCl2) for 3 months, group 3 (NAC cotreatment group) received CdCl2 and 0.5% NAC in tap water for 3 months, group 4 received CdCl2 in tap water for 3 months and 3 months later received only tap water for 7 days, and group 5 (NAC posttreatment group) received CdCl2 in tap water for 3 months and 3 months later received 2% NAC in tap water for 7 days. NAC significantly decreased the elevated kidney malondialdehyde levels, as a marker of lipid peroxidation, in both cotreatment and posttreatment modalities. Cotreatment and posttreatment with NAC significantly increased kidney superoxide dismutase enzyme activity and glutathione level but did not change kidney catalase enzyme activity. NAC decreased fractional excretion of sodium in posttreatment group. Neither Cd nor NAC affected the glomerular filtration rate (GFR). Cotreatment and posttreatment with NAC reduced the effects of Cd on proximal tubules. It was found that NAC showed these effects without changing kidney accumulation of cadmium. Exogenously administrated NAC might reduce toxic effects of Cd on the kidney without any reduction in tissue Cd level.en_US
dc.identifier.doi10.1007/s00467-007-0696-7
dc.identifier.endpage241en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue2en_US
dc.identifier.pmid18064495en_US
dc.identifier.scopus2-s2.0-38349018491en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-007-0696-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18584
dc.identifier.volume23en_US
dc.identifier.wosWOS:000252298600008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Enzymeen_US
dc.subjectCadmiumen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectNephrotoxicityen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectGlutathioneen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectSuperoxideen_US
dc.subjectMechanismsen_US
dc.subjectSeleniumen_US
dc.subjectNephrotoxicityen_US
dc.subjectAccumulationen_US
dc.subjectProtectionen_US
dc.titleInfluence of N-acetylcysteine on renal toxicity of cadmium in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu