The potential cardioprotective effects of amifostine in irradiated rats

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dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorTokatli, F
dc.contributor.authorUzal, C
dc.contributor.authorDoganay, L
dc.contributor.authorKocak, Z
dc.contributor.authorKaya, M
dc.contributor.authorTure, M
dc.contributor.authorKurum, T
dc.date.accessioned2024-06-12T10:55:09Z
dc.date.available2024-06-12T10:55:09Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study is to determine the cardioprotective efficacy of amifostine. The study consists of researching the relationship between plasma brain natriuretic peptide levels and the electrical and morphologic changes in irradiated rats with or without amifostine. Methods and Materials: Sixty Wistar albino rats were divided into 4 groups, and their hearts were given 15 Gy/fraction with Co-60. In Groups I and II, the rats were killed after 24 hours to detect early effects; in Groups III and IV, the rats were killed 100 days after irradiation to detect late effects. Before irradiation, Groups I and III received 0.9% saline solution, whereas Groups II and IV received amifostine (200 mg/kg). Twenty rats were used as a control group. Results: On the 100th day, mild myocardial degeneration was detected in 5 rats (33%) from Group III (no amifostine). This percentage was statistically different from that of Group IV (treated with amifostine) and the controls (p = 0.042). There was no statistically significant difference between the mean plasma brain natriuretic peptide values of the groups (p > 0.05). There was no significant difference in electrocardiographies between the groups. There was no correlation between continuous variables. Conclusion: In the amifostine group (IV) on the 100th day, there was no myocardial degeneration, suggesting that amifostine has a cardioprotective effect. (C) 2004 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.ijrobp.2003.09.071
dc.identifier.endpage1234en_US
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.issue4en_US
dc.identifier.pmid15001267en_US
dc.identifier.scopus2-s2.0-12144290580en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1228en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijrobp.2003.09.071
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19299
dc.identifier.volume58en_US
dc.identifier.wosWOS:000220084200028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal Of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain Natriuretic Peptideen_US
dc.subjectAmifostineen_US
dc.subjectRadiationen_US
dc.subjectCardiac Toxicityen_US
dc.subjectMyocardial Damageen_US
dc.subjectAtrial-Natriuretic-Peptideen_US
dc.subjectInduced Heart-Diseaseen_US
dc.subjectHodgkins-Diseaseen_US
dc.subjectCardiac Damageen_US
dc.subjectDoxorubicin Treatmenten_US
dc.subjectNormal-Tissuesen_US
dc.subjectBreast-Canceren_US
dc.subjectNeck-Canceren_US
dc.subjectFollow-Upen_US
dc.subjectRadiotherapyen_US
dc.titleThe potential cardioprotective effects of amifostine in irradiated ratsen_US
dc.typeArticleen_US

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