Mortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter study

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dc.authoridGozel, Mustafa Gokhan/0000-0001-5187-7388
dc.authoridAlkan, Sevil/0000-0003-1944-2477
dc.authoridLeblebicioglu, Hakan/0000-0002-6033-8543
dc.authoridbalkan, ilker inanc/0000-0002-8977-5931
dc.authoridaltay, fatma aybala/0000-0002-7149-2968
dc.authoridVahaboglu, H/0000-0001-8217-1767
dc.authoridŞencan-1, İrfan/0000-0003-0465-5090
dc.authorwosidYetkin, Meltem Arzu/GQB-0055-2022
dc.authorwosidGozel, Mustafa Gokhan/ABG-1439-2020
dc.authorwosidBodur, Hürrem/GRO-2410-2022
dc.authorwosidAlkan, Sevil/ABH-8663-2020
dc.authorwosidAkalin, Halis/AAU-8952-2020
dc.authorwosidLeblebicioglu, Hakan/A-3960-2016
dc.authorwosidARSLAN, FERHAT/ABG-5757-2021
dc.contributor.authorYilmaz, Mesut
dc.contributor.authorElaldi, Nazif
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorArslan, Ferhat
dc.contributor.authorBatirel, Ayse Alga
dc.contributor.authorBakici, Mustafa Zahir
dc.contributor.authorGozel, Mustafa Gokhan
dc.date.accessioned2024-06-12T11:15:38Z
dc.date.available2024-06-12T11:15:38Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Staphylococcus aureus is one of the causes of both community and healthcare-associated bacteremia. The attributable mortality of S. aureus bacteremia (SAB) is still higher and predictors for mortality and clinical outcomes of this condition are need to be clarified. In this prospective observational study, we aimed to examine the predictive factors for mortality in patients with SAB in eight Turkish tertiary care hospitals. Methods: Adult patients with signs and symptoms of bacteremia with positive blood cultures for S. aureus were included. All data for episodes of SAB including demographics, clinical and laboratory findings, antibiotics, and outcome were recorded for a 3-year (2010-2012) period. Cox proportional hazard model with forward selection was used to assess the independent effect of risk factors on mortality. A 28-day mortality was the dependent variable in the Cox regression analysis. Results: A total of 255 episodes of SAB were enrolled. The median age of the patients was 59 years. Fifty-five percent of the episodes were considered as primary SAB and vascular catheter was the source of 42.1 %. Healthcare associated SAB was defined in 55.7 %. Blood cultures yielded methicillin-resistant S. aureus (MRSA) as a cause of SAB in 39.2 %. Initial empirical therapy was inappropriate in 28.2 %. Although overall mortality was observed in 52 (20.4 %), 28-day mortality rate was 15.3 %. Both the numbers of initial inappropriate empirical antibiotic treatment and the median hours to start an appropriate antibiotic between the cases of fatal outcome and survivors after fever onset were found to be similar (12/39 vs 60/216 and 6 vs 12 h, respectively; p > 0.05). High Charlson comorbidity index (CCI) score (p = 0.002), MRSA (p = 0.017), intensive care unit (ICU) admission (p < 0.001) and prior exposure to antibiotics (p = 0.002) all were significantly associated with mortality. The Cox analysis defined age [Hazard Ratio (HR) 1.03; p = 0.023], ICU admission (HR 6.9; p = 0.002), and high CCI score (HR 1.32; p = 0.002) as the independent predictive factors mortality. Conclusions: The results of this prospective study showed that age, ICU stay and high CCI score of a patient were the independent predictors of mortality and MRSA was also significantly associated with mortality in SAB.en_US
dc.identifier.doi10.1186/s12941-016-0122-8
dc.identifier.issn1476-0711
dc.identifier.scopus2-s2.0-84957870054en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12941-016-0122-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23996
dc.identifier.volume15en_US
dc.identifier.wosWOS:000369571000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofAnnals Of Clinical Microbiology And Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectBacteremiaen_US
dc.subjectRisk Factorsen_US
dc.subjectMortalityen_US
dc.subjectSepsisen_US
dc.subjectBlood-Stream Infectionen_US
dc.subjectHacettepe University Adulten_US
dc.subjectMethicillin-Resistanten_US
dc.subjectRisk-Factorsen_US
dc.subjectClinical Impacten_US
dc.subjectAntimicrobial Therapyen_US
dc.subjectAntibiotic-Treatmenten_US
dc.subject30-Day Mortalityen_US
dc.subjectEndocarditisen_US
dc.subjectEpidemiologyen_US
dc.titleMortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter studyen_US
dc.typeArticleen_US

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