Relationship with plasma neurohormones and dyssynchrony detected by Doppler echocardiography in patients undergoing permanent pacemaker implantation

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dc.authoridsöyük, selma/0000-0001-9822-9417
dc.authorwosidsöyük, selma/V-5634-2017
dc.contributor.authorKürüm, T
dc.contributor.authorYüksel, M
dc.contributor.authorÖzbay, G
dc.contributor.authorSöyük, S
dc.contributor.authorTüre, M
dc.date.accessioned2024-06-12T11:12:18Z
dc.date.available2024-06-12T11:12:18Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective - To determine whether isovolumic relaxation flow (IRF) and isovolumic contraction flow (ICF) resulted from asynchrony and asynergy due to VVI and DDD pacemakers modulated neurohormones, we measured neurohormone levels in plasma and investigated the characteristics of IRF and ICF using Doppler echocardiography. Methods and results - We studied 11 patients with dual-chamber pacemakers (DDD) and 11 patients, with ventricular inhibiting mode (VVI). All patients underwent Doppler echocardiography of the left ventricle. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), renin and aldosteron were measured. The LV was scanned for the presence of intracavitary flow during the isovolumic relaxation and isovolumic contraction period. The plasma levels of BNP and ANP were significantly lower in DDD mode than in VVI mode (56+/-32 pg/ml vs. 94+/-32 pg/ml, p=0.022 and 98+/-20 pg/ml vs. 134+/-17 pg/ml, p=0.042, respectively). There were no significant differences in the plasma level of renin or aldosteron. VVI mode versus DDD mode increased isovolumic relaxation flow time (129+/-41 vs. 111+/-36 sec, p = 0.020) and isovolumic relaxation flow velocity (50+/-4 vs. 37+/-2 cm/s, p=0.018). A strong relationship between blood ANP and BNP levels and IRF velocity was found in patients with a VVI pacemaker (r: 0.632, p: 0.028; r: 0.528, p: 0.024, respectively). Conclusion - VVI mode has a longer isovolumic relaxation time, isovolumic relaxation flow velocity and has higher ANP and BNP plasma levels than DDD mode. IRF resulting from asynergy and asynchrony in VVI mode pacemakers versus DDD mode pacemakers affects the plasma levels of ANP and BNP compared to renin and alclosteron.en_US
dc.identifier.doi10.2143/AC.58.6.2005313
dc.identifier.endpage505en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue6en_US
dc.identifier.pmid14713174en_US
dc.identifier.scopus2-s2.0-18744434405en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://doi.org/10.2143/AC.58.6.2005313
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23108
dc.identifier.volume58en_US
dc.identifier.wosWOS:000187414900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPermanent Pacemakeren_US
dc.subjectDoppler Echocardiographyen_US
dc.subjectIsovolumic Relaxation Flowen_US
dc.subjectIsovolumic Contraction Flowen_US
dc.subjectPlasma Neurohormonesen_US
dc.subjectAtrial-Natriuretic-Peptideen_US
dc.subjectLeft-Ventricular Relaxationen_US
dc.subjectIsovolumetric-Relaxationen_US
dc.subjectHeart-Failureen_US
dc.subjectFlowen_US
dc.subjectCardioversionen_US
dc.subjectReleaseen_US
dc.subjectAnpen_US
dc.titleRelationship with plasma neurohormones and dyssynchrony detected by Doppler echocardiography in patients undergoing permanent pacemaker implantationen_US
dc.typeArticleen_US

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