An increased frequency of gallbladder stones in rheumatoid arthritis patients. Factors related to gallbladder stone formation
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Tarih
2006
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective. In this study, we determined the frequency of gallbladder stone (GBS) in rheumatoid arthritis (RA) patients and evaluated factors which could affect the formation of GBS - such as lipids and the GB motilities of the patients. Methods. One hundred and thirteen RA patien ts (92F, 21M, mean disease duration: 8.9 years) and 117 healthy controls (94F, 23M) were included. In all RA patients, the clinical findings were recorded down; biochemical parameters and body mass index (BMI) were determined; and, abdominal ultrasonography was performed. In addition, 16 RA patients and 20 controls who were age-matched were randomly chosen for GB emptying monitored by ultrasound at 30-minute intervals for 2 hours after a mixed meal. Fasting volume (FV), residual volume (RV) and ejection fraction (EF) for all GBs were assessed. Results. There was a tendency towards a higher frequency of GBS including cholecyctectomy (11 GBS, 11 cholecystectomy, 19.5%) in RA patients when compared to controls (8 GBS, 5 cholecystectomy, 11.1%) (p = 0.08). The frequency of GBS plus cholecyctectomy in female RA patients (22.8%) was significantly higher than the control group (11.7%, p = 0.044). Logistic regression analysis showed that only older age was significantly associated with the presence of GBS in RA (OR:1.05, p = 0.048). There was no difference between the 2 groups in FV (p > 0.05). RV, PRV and EF were significantly higher in RA patients than in the control group (p < 0.05). Conclusions. We diagnosed a higher frequency of GBS in female RA patients when compared to controls. Impaired GB motility in RA patients might contribute to an increased incidence of GBS development. © Copyright Clinical and Experimental Rheumatology 2006.
Açıklama
Anahtar Kelimeler
Gallbladder Motility; Gallstone; Non-Steroidal Anti-Inflammatory Drugs; Rheumatoid Arthritis, Disease Modifying Antirheumatic Drug; Hydroxychloroquine; Methotrexate; Nonsteroid Antiinflammatory Agent; Salazosulfapyridine; Steroid; Adult; Aged; Article; Body Mass; Cholecystectomy; Cholelithiasis; Controlled Study; Diet Restriction; Disease Duration; Echography; Female; Gallbladder Dysmotility; Gallbladder Emptying; Gallbladder Motility; Human; Incidence; Logistic Regression Analysis; Major Clinical Study; Male; Pathogenesis; Priority Journal; Rheumatoid Arthritis; Risk Factor; Sex Difference; Statistical Significance; Stone Formation; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cholecystectomy; Cholecystolithiasis; Female; Gallbladder; Gallbladder Emptying; Gallstones; Humans; Male; Middle Aged; Risk Factors; Turkey
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
24
Sayı
3
