Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease

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dc.authoridBOZKURT, SÜHEYLA UYAR/0000-0002-5947-947X
dc.authoridBOZKURT, SUHEYLA UYAR uyar/0000-0002-5947-947X
dc.authoridAras, Adem bozkurt/0000-0002-0140-5224
dc.authoridElmaci, Ilhan/0000-0001-9433-0307
dc.authoridBalak, Naci/0000-0002-2395-0004
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authorwosidBOZKURT, SÜHEYLA UYAR/JVO-9637-2024
dc.authorwosidBOZKURT, SUHEYLA UYAR uyar/A-8912-2016
dc.authorwosidAras, Adem bozkurt/HTN-3829-2023
dc.authorwosidElmaci, Ilhan/AAF-3459-2021
dc.authorwosidGuven, Mustafa/C-7731-2013
dc.authorwosidBalak, Naci/D-5846-2019
dc.authorwosidguven, mustafa/I-6840-2013
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorGuven, Mustafa
dc.contributor.authorBalak, Naci
dc.contributor.authorAyan, Erdogan
dc.contributor.authorUyar, Suheyla Bozkurt
dc.contributor.authorElmaci, Ilhan
dc.date.accessioned2024-06-12T11:03:56Z
dc.date.available2024-06-12T11:03:56Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: The intervertebral disc starts to degenerate when a human being begins to stand and learn to walk. It is known that many extrinsic, intrinsic and genetic factors play a role in disc degeneration. In this study, we examined whether the matrix metalloproteinase 11 might be associated with intervertebral disc degeneration. MATERIAL and METHODS: Fifty-six patients with lumbar disc herniations who were operated at Gortepe Education and Research Hospital, Neurosurgery Clinic between September 2008 and December 2009 were prospectively reviewed. History and complaints were obtained from the case reports. Neuroradiological evaluation was performed with magnetic resonance imaging. Surgical findings of cases were reported in the operation notes. Microscopic posterior hemipartial laminectomy and discectomy were performed in all cases. Degenerated herniated disc material of all cases extracted during surgery was evaluated with immunohistochemical staining in Marmara University, Institute of Neurological Sciences, Pathology Laboratory. RESULTS: Comparing the immunohistochemical staining of cases who were 50 years or younger and cases who were over 50 years old, statistical significance was determined. CONCLUSION: Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease, but it is not the only factor. Matrix metalloproteinase 11 might be a genetic factor in young-middle aged patients.en_US
dc.identifier.doi10.5137/1019-5149.JTN.12762-14.0
dc.identifier.endpage279en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid26956825en_US
dc.identifier.scopus2-s2.0-84964661494en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage274en_US
dc.identifier.trdizinid210313en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.12762-14.0
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/210313
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21851
dc.identifier.volume26en_US
dc.identifier.wosWOS:000372668700017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntervertebral Disc Degenerationen_US
dc.subjectIntervertebral Disc Displacementen_US
dc.subjectMatrix Metalloproteinase 11en_US
dc.subjectMiddle Ageen_US
dc.subjectDegenerationen_US
dc.subjectCellsen_US
dc.subjectExpressionen_US
dc.subjectGrowthen_US
dc.subjectVolvoen_US
dc.subjectRisken_US
dc.titleEvaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Diseaseen_US
dc.typeArticleen_US

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