Ameliorative Effect of Omega-3 in Carbon Tetrachloride Toxicity

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authorwosiddağ, serpil/AAZ-6755-2020
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.contributor.authorKaraman, Musa
dc.contributor.authorOzen, Hasan
dc.contributor.authorDag, Serpil
dc.contributor.authorAtakisi, Onur
dc.contributor.authorCigsar, Gulsen
dc.contributor.authorKaya, Oktay
dc.date.accessioned2024-06-12T10:55:58Z
dc.date.available2024-06-12T10:55:58Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOmega-3 is a polyunsaturated fatty acid known to have immunomodulatory functions. In the present study, ameliorative potential of omega-3 in experimental carbon tetrachloride (CCl4) toxicity was investigated. Total of 40 adult male Wistar albino rats were allocated into five groups and were subcutaneously given once every two days for 6 weeks the followings: Group 1 (Control): 0.5 ml/kg serum physiologic, Group 2 (Omega): 0.5 g/kg omega-3, Group 3 (Vehicle): 0.5 ml/kg pure olive oil, Group 4 (CCl4): 0.5 ml/kg CCl4, Group 5 (CCl4 + Omega): 0.5 ml/kg CCl4 plus 0.5 g/kg omega-3. At the end of the treatments, blood samples were collected and necropsy was performed for collection of liver tissues. Serum AST, ALT, GGT, TAC, TOC, triglyceride, and visfatin levels were detected. Liver morphology and immunoreactivities against TGF-alpha, TGF-beta, PPAR-alpha, and PPAR-gamma were assessed. Serum AST, ALT, GGT, and TOC levels significantly increased while TAC level decreased in CCl4 given animals as compared to the control group. No significant changes were observed in triglyceride and visfatin levels. Immunohistochemical staining revealed increased TGF-alpha and TGF-beta expressions and decreased PPAR-alpha and PPAR-gamma expressions in liver of CCl4 given animals. Omega-3 supplementation has prominent effects in correcting the biochemical and immunohistochemical parameters studied as well as the tissue morphology. The results of the investigation indicated that omega-3 has ameliorative effects on the oxidative tissue degeneration and inflammatory processes induced by CCl4 treatment in rats.en_US
dc.description.sponsorshipScientific Research Fund of Kafkas University [BAP VF 07-2014]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Kafkas University (Project No: BAP VF 07-2014)en_US
dc.identifier.doi10.9775/kvfd.2016.15862
dc.identifier.endpage85en_US
dc.identifier.issn1300-6045
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84992461891en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2016.15862
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19619
dc.identifier.volume23en_US
dc.identifier.wosWOS:000388115200011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCcl4en_US
dc.subjectOmega-3en_US
dc.subjectTGF-Alphaen_US
dc.subjectTGF-Betaen_US
dc.subjectPPAR-Alphaen_US
dc.subjectPPAR-Gammaen_US
dc.subjectActivated Receptor-Gammaen_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectInduced Liver Fibrosisen_US
dc.subjectGrowth-Factor-Alphaen_US
dc.subjectHepatic-Fibrosisen_US
dc.subjectPpar-Alphaen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFatty-Acidsen_US
dc.subjectIn-Vivoen_US
dc.subjectInjuryen_US
dc.titleAmeliorative Effect of Omega-3 in Carbon Tetrachloride Toxicityen_US
dc.typeArticleen_US

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