The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl

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dc.contributor.authorMemis, D
dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorSüt, N
dc.contributor.authorPamukçu, Z
dc.date.accessioned2024-06-12T11:19:59Z
dc.date.available2024-06-12T11:19:59Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe compared the efficacy of ondansetron, lidocame, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients. After tourniquet application on the forearm, the patients were given saline (3 mL) (Group 1, n = 50), ondansetron (4 mg) (Group 2, n = 50), lidocaine (30 mg) (Group 3, n = 50), tramadol (50 mg) (Group 4, n = 50), or fentanyl (100 mug) (Group 5, n = 50) diluted into a 3-mL solution. The occlusion was released after 20 s and rocuronium was injected over 10-15 s. The patients were observed and asked immediately if they had pain in the arm, and the response was assessed. Reactions such as discomfort and pain, withdrawal of the hand, and so on after the administration of rocuronium were recorded as side effects for 24 h. Ten patients in Group 1, 28 patients in Group 2, 37 patients in Group 3, 30 patients in Group 4, and 15 patients in Group 5 reported no pain. Light pain was seen in 11 patients in Group 1, 14 patients in Group 2, 11 patients in Group 3,12 patients in Group 4, and 20 patients in Group 5. Moderate pain was seen in 15 patients in Group 1, 6 patients in Group 2, 2 patients in Group 3, 8 patients in Group 4, and 10 patients in Group 5. Severe pain was seen in 14 patients in Group 1, 2 patients in Group 2, 0 patients in Group 3, 0 patients in Group 4, and 5 patients in Group 5. Correlation determined with log-linear analysis found in Group I pain score 0 (P < 0.001), Group 1 pain score 1 (P < 0.001), and Group 3 pain score 0 (P < 0.001). We conclude that ondansetron, lidocaine, tramadol, and fentanyl decrease the level of rocuronium injection pain. Among these drugs, lidocame is the most effective, whereas fentanyl is the least effective.en_US
dc.identifier.doi10.1097/00000539-200206000-00026
dc.identifier.endpage1520en_US
dc.identifier.issn0003-2999
dc.identifier.issue6en_US
dc.identifier.pmid12032018en_US
dc.identifier.scopus2-s2.0-0036265022en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1517en_US
dc.identifier.urihttps://doi.org/10.1097/00000539-200206000-00026
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25415
dc.identifier.volume94en_US
dc.identifier.wosWOS:000175890900027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpontaneous Movementsen_US
dc.subjectPropofol Injectionen_US
dc.subjectPharmacologyen_US
dc.subjectPretreatmenten_US
dc.titleThe prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanylen_US
dc.typeArticleen_US

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