Radioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatment

Basit Öğe Kaydı
dc.authoridTorun, Nese/0000-0002-5597-676X
dc.authorwosidTorun, Nese/AAE-2718-2021
dc.contributor.authorTorun, Nese
dc.contributor.authorMuratli, Asli
dc.contributor.authorSerim, Burcu Dirlik
dc.contributor.authorErgulen, Alev
dc.contributor.authorAltun, Gulay Durmus
dc.date.accessioned2024-06-12T11:13:21Z
dc.date.available2024-06-12T11:13:21Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Standard treatment of differentiated thyroid cancer includes total thyroidectomy and high-dose Radioactive Iodine Therapy (RIT) for ablation of remnant thyroid tissue. When administered systemically, RIT can cause radiation-induced damage in non-targeted normal tissues. The aim of the present study was to compare the protective effects of amifostine (AMI), L-Carnitine (LC), and Vitamin E (EVIT) against high dose radioactive iodine treatment induced Salivary Gland (SG) damage using SG scintigraphy and histopathological examination. Methods: Forty adult guinea pigs were studied. Twenty guinea pigs receive 555-660 MBq (131)Iodine intraperitoneally (IP) to ablate the thyroid and impair the parenchymal function of the SGs. The animals were divided into eight groups as follows: (1) Group 1 (control): 1 mL IP PS (physiological saline); (2) Group 2: single dose of 200 mg/kg IP AMI one hour prior to 1 mL IP PS; (3) Group 3: 200 mg/kg IP LC and 1 mL IP PS for 10 days; (4) Group 4: 40 mg/kg intramuscular (IM) EVIT and 1 mL IP PS for 10 days; (5) Group 5: IP RIT after premedication; (6) Group 6: Single dose of 200 mg/kg IP AMI one hour prior to RIT and IP RIT after premedication; (7) Group 7: IP RIT after premedication and 200 mg/kg IP LC for 10 days starting one day before RIT; and (8) Group 8: IP RIT after premedication and 40 mg/kg IM EVIT for 10 days starting one day before RIT. Scintigraphy was performed 1 month after treatment. SGs were examined by light microscopy and a histopathological scoring system was used to assess the degree of SG damage. Results: There were significant differences in the body weight and thyroid hormone levels between the groups after treatment. Conclusion: The individual use of AMI, LC and EVIT for radioprotection yield different levels of protection against radioactive iodine treatment injury in SGs; however, none of the agents could provide absolute protection at the doses administered in this experimental model.en_US
dc.identifier.doi10.2174/1573405614666180314150808
dc.identifier.endpage404en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue4en_US
dc.identifier.pmid31989909en_US
dc.identifier.scopus2-s2.0-85065960811en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.2174/1573405614666180314150808
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23511
dc.identifier.volume15en_US
dc.identifier.wosWOS:000464162000007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Medical Imaging Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadioactive Iodine Therapyen_US
dc.subjectSalivary Glanden_US
dc.subjectAmifostineen_US
dc.subjectL-Carnitineen_US
dc.subjectVitamin Een_US
dc.subjectThyroid Canceren_US
dc.subjectRadioiodine Therapyen_US
dc.subjectRadiationen_US
dc.subjectScintigraphyen_US
dc.subjectCombinationen_US
dc.subjectDysfunctionen_US
dc.subjectProtectionen_US
dc.subjectToxicityen_US
dc.titleRadioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatmenten_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu