Synthesis, spectral analysis, antimicrobial, cytotoxicity, and antioxidant studies of gold(III) complex of caffeine

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dc.contributor.authorAltun, Ozlen
dc.contributor.authorSuozer, Mehtap
dc.date.accessioned2024-06-12T11:02:47Z
dc.date.available2024-06-12T11:02:47Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present study, the reactions involving caffeine (CA) and gold(III) were investigated. The synthesized complex was characterized by using mass, UV-visible, FTIR, H-1 and C-13 NMR, and TG-DTA analyses. From these analyses, it is predicted that the complex has the formula [Au(CA)(2)(Cl)(2)]Cl. In addition, antimicrobial, cytotoxicity, and antioxidant activities of the obtained complex were investigated. Investigation of antimicrobial properties demonstrated that the complex has important antibacterial and antifungal activities. The cytotoxic activity of the complex showed potent cytotoxicity against growth of human prostate (Du145), cervix (HeLa), colon (HT29), and breast (MCF7) cancer cells. Additionally, the complex showed significant antioxidant activity.en_US
dc.description.sponsorshipTrakya University [TUBAP-2010/72]; Trakya Universityen_US
dc.description.sponsorshipWe thank Trakya University TUBAP-2010/72 for financial support. We confirm that Trakya University only provided financial support within the scope of the project for chemicals in the manuscript and we declare that the support received did not lead to any financial conflict of interests regarding the publication of this manuscript. There is no need for Trakya University's confirmation to publish this manuscript.en_US
dc.identifier.doi10.1080/00958972.2019.1629430
dc.identifier.endpage2105en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85067860964en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2091en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2019.1629430
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21398
dc.identifier.volume72en_US
dc.identifier.wosWOS:000475118200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGold(III)en_US
dc.subjectSpectral Analysisen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectN-Heterocyclic Carbenesen_US
dc.subjectNatural-Products Synthesisen_US
dc.subjectIn-Vitro Cytotoxicityen_US
dc.subjectSpectrophotometric Determinationen_US
dc.subjectCorresponding Gold(I)en_US
dc.subjectBiological-Activityen_US
dc.subjectSolution Chemistryen_US
dc.subjectAntitumor-Activityen_US
dc.subjectAnticanceren_US
dc.subjectAu(Iii)en_US
dc.titleSynthesis, spectral analysis, antimicrobial, cytotoxicity, and antioxidant studies of gold(III) complex of caffeineen_US
dc.typeArticleen_US

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