Ratlarda oluşturulan deneysel yanık iyileşmesinde lineer polarize polikromatik ışığın etkileri
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
ÖZET Yapılan çalışmada, bir fizik tedavi ajanı olan LPPI'ın yanık yarasında, iyileşme üzerine olan etkileri araştırıldı. Kontrollü, tek kör yapılan bu deneysel çalışmada, 21 SD cinsi rat kullanıldı. Ancak bir ratın bilinmeyen bir nedenle ölmesi üzerine, çalışma 20 rat ile tamamlandı. Oluşturulan yanık yaraları iki gruba ayrılarak, bir gruba 14 gün boyunca günde iki seans açık pansuman, LPPI ve antibakteriyel pomad uygulandı. Diğer grup ise kontrol grubu olarak alındı ve LPPI uygulanmadı. Yanık yaralarındaki iyileşme, 21 gün boyunca izlendi. Oluşturulan skorlama sistemine göre, makroskopik ve histopatolojik olarak iyileşme değerlendirildi. Makroskopik olarak; yara alanı kapanma oranı ve boyutu, ödem, hiperemi ve epitelizasyon, histopatolojik olarak ise alınan seri biyopsilerde; epitelizasyon, granülasyon dokusu, inflamasyon ve vaskülarizasyon değerlendirildi. Aynı zamanda oluşturulan total skorlama sistemi ile histopatolojik olarak iyileşme bir bütün olarak incelendi. Makroskopik olarak yara alanı kapanma oranı ve epitelizasyon oluşumu LPPI uygulanan grupta daha fazlaydı (p<0.05). Yara alanı boyutu, hiperemi ve ödemin ise LPPI uygulanan grupta daha az olduğu saptandı (p<0.05). Histopatolojik olarak yapılan incelemede ise epitelizasyon LPPI uygulanan grupta daha fazla saptandı ancak bu farklılık 7. gün istatistiksel olarak anlamlıydı. Vaskülarizasyon LPPI uygulanan grupta daha fazlaydı ancak bu fark 21. gün yapılan incelemede istatistiksel olarak anlamlı bulundu. Granülasyon dokusu oluşumu ve inflamasyon da her iki grup arasında anlamlı bir fark saptanmadı (p>0.05). Ayrıca, total skorlamada LPPI uygulanan grupta ilk hafta anlamlı bir iyileşme olduğu saptanmıştır (p<0.05). 57Sonuç olarak, LPPI kullanımının yanık yarası iyileşmesinde özellikle ilk hafta etkin olduğu saptanmıştır. Çalışma sonucunda elde edilen bulgular bu ışık ile ilgili diğer yayınlarla uyumlu olduğu gözlenmiştir. 58
THE EFFECT OF LINEAR POLARISED POLYCHROMATIC LIGHT ON EXPERIMENTAL BURN HEALING IN RATS SUMMARY In this study, effects of a physical therapy agent, called LPPI, on burn healing were investigated. Twenty one SD rats were used in this controlled, single blind experimental study. As one rat died due to an unidentified reason, the study was carried with 20 rats. The burns were divided into two groups. The treatment group were treated with open dressing, LPPI and antibacterial pomade twice a day during 14 days. The burns in the control group were treated the same except for LPPI application. Bum healing were assessed during 21 days. Healing was evaluated macroscopically and histopathologically according to accepted scoring systems. Macroscopic parameters evaluated were; healing rate, area of healing, edema, hyperemia and epithelialization, while the histopathologic parameters obtained from serial biopsies were epithelialization, granulation, inflammation and vascularization. Total scoring system evaluated the whole hystopathological healing. Macroscopic healing rate and epithelialization were much more in the LPPI treated group (p<0,05). Area of burn, hyperemia and edema were lower in the treatment group (p<0,05). In the hystopathological evaluation epithelialization was much more in the treatment group and the difference between the groups was significant on the 7th day. Vascularization was higher in the LPPI treated group and the difference between the groups were found to be significant on the 21st day. There was no difference between the groups in terms of 59granulation tissue formation and inflammation (p>0,05). According to the total scoring system, healing was more significant in LPPI treated group after the first week (p<0,05). As a result, it was determined that LPPI use was found to be effective on burn healing especially during the first week. The results, seems to be parallel with the current literature. 60
THE EFFECT OF LINEAR POLARISED POLYCHROMATIC LIGHT ON EXPERIMENTAL BURN HEALING IN RATS SUMMARY In this study, effects of a physical therapy agent, called LPPI, on burn healing were investigated. Twenty one SD rats were used in this controlled, single blind experimental study. As one rat died due to an unidentified reason, the study was carried with 20 rats. The burns were divided into two groups. The treatment group were treated with open dressing, LPPI and antibacterial pomade twice a day during 14 days. The burns in the control group were treated the same except for LPPI application. Bum healing were assessed during 21 days. Healing was evaluated macroscopically and histopathologically according to accepted scoring systems. Macroscopic parameters evaluated were; healing rate, area of healing, edema, hyperemia and epithelialization, while the histopathologic parameters obtained from serial biopsies were epithelialization, granulation, inflammation and vascularization. Total scoring system evaluated the whole hystopathological healing. Macroscopic healing rate and epithelialization were much more in the LPPI treated group (p<0,05). Area of burn, hyperemia and edema were lower in the treatment group (p<0,05). In the hystopathological evaluation epithelialization was much more in the treatment group and the difference between the groups was significant on the 7th day. Vascularization was higher in the LPPI treated group and the difference between the groups were found to be significant on the 21st day. There was no difference between the groups in terms of 59granulation tissue formation and inflammation (p>0,05). According to the total scoring system, healing was more significant in LPPI treated group after the first week (p<0,05). As a result, it was determined that LPPI use was found to be effective on burn healing especially during the first week. The results, seems to be parallel with the current literature. 60
Açıklama
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Tıpta Uzmanlık
Tıpta Uzmanlık
Anahtar Kelimeler
Fiziksel Tıp ve Rehabilitasyon, Physical Medicine and Rehabilitation
