Mirtazapine Treatment for Comorbid Anxiety/Depressive Disorders in Young Subjects with Attention-Deficit Hyperactivity Disorder: Case Series
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kure Iletisim Grubu A S
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To investigate the efficacy and tolerability of mirtazapine combination with methylphenidate in young subjects with diagnosis of attention deficit hyperactivity disorder (ADHD) and comorbid anxiety or depressive disorders. Method: Subjects with DSM-IV diagnosis of ADHD and comorbid anxiety or depressive disorders were added mirtazapine 7.5 or 15 mg/day initially to treat anxiety or depressive disorders as well as to counteract or avoid methylphenidate or SSRIs related side effects. Improvement in target symptoms were assessed using relevant scales and the Clinical Global Impression-improvement (CGI-1) scale. Results: Subjects were four boys and three girls (11.85 +/- 2.91 years). Duration of methylphenidate and mirtazapine treatment was 14.28 +/- 9.41 and 3.71 0.95 months respectively. Final dose of mirtaza pine was 16 +/- 2.64 mg/day. All subjects showed moderate to very much improvement in sleep and three subjects showed much improvement in appetite problems on CGI-I scale. Six subjects showed mild to very much improvement in anxiety disorders /symptoms and one subject showed much improvement in depression on CGI-I scale. Mirtazapine was generally tolerated well. Most frequently reported side effects were increased appetite (n=5), weight gain (n=4; 1000-4000 gm; 1357.14 +/- 1546.88 gm); day time sedation (n=4) and irritability (n=2). Conclusions: Young subjects with diagnosis of ADHD and comorbid anxiety or depressive disorders may benefit from mirtazapine addition particularly in the presence of methylphenidate or SSRIs related sleep and/or appetite problems.
Açıklama
Anahtar Kelimeler
Anxiety, ADHD, Depression, Comorbidity, Mirtazapine, Treatment, Deficit/Hyperactivity Disorder, Open-Label, Psychiatric Comorbidity, Sleep Problems, Children, Anxiety, Adolescents, Atomoxetine, Depression, Fluoxetine
Kaynak
Klinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacology
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
20
Sayı
3
