Association of maternal serum high sensitive C-reactive protein level with body mass index and severity of pre-eclampsia at third trimester

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dc.authorwosidYilmaz, Bulent/GPK-8613-2022
dc.authorwosidYilmaz, Bulent/HKE-5048-2023
dc.authorwosidOzel, Murat/O-5104-2018
dc.contributor.authorErtas, Ibrahim E.
dc.contributor.authorKahyaoglu, Serkan
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorOzel, Murat
dc.contributor.authorSut, Necdet
dc.contributor.authorGuven, Melih A.
dc.contributor.authorDanisman, Nuri
dc.date.accessioned2024-06-12T10:50:53Z
dc.date.available2024-06-12T10:50:53Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: To assess a maternal serum level of high sensitive C-reactive protein (hs-CRP) as a useful clinical parameter in prediction of pre-eclampsia severity and, to evaluate the correlation between hs-CRP and body mass index (BMI). Material & Methods: Using cross-sectional study design, CRP was measured by a high sensitive immunoturbidimetric method between 24 and 40 weeks of gestation in normotensive controls (n = 115), in mild (n = 63) and severe (n = 34) pre-eclamptic patients. The receiver operating characteristic analysis was used to estimate the optimal threshold score of hs-CRP. Results: For disease severity evaluation, a hs-CRP concentration of 9.66 mg/L was determined as cut-off point with 88% sensitivity, 81% specificity, 71% positive predictive value and 92% negative predictive value. When all three groups of patients were adjusted for gestational age [24 degrees/7-27,6/7 28 degrees/7-33,6/7 34 degrees/7-406/7] and BMI, hs-CRP levels of severe pre-eclamptic patients were significantly higher than mild ones and controls in the study group with BMI < 25 kg/m2 (P < 0.001). In the study group with BMI >= 25 kg/m2, only severe pre-eclamptic patients between 28 degrees/7 and 336/7 weeks of gestation had significantly higher hs-CRP levels when compared with control and mild pre-eclamptic group (P < 0.001). When the patients were subgrouped as high (>= 9.66 mg/L) and low hs-CRP group (< 9.66 mg/L), adverse outcomes for hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome and intrauterine growth-restricted baby were statistically significant higher in high hs-CRP group (P = 0.004 and P < 0.001, respectively). Conclusion: Elevated level of hs-CRP is a useful parameter in the severity of clinical risk of pre-eclampsia in patients with BMI < 25 kg/m2 at third trimester.en_US
dc.identifier.doi10.1111/j.1447-0756.2010.01279.x
dc.identifier.endpage977en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue5en_US
dc.identifier.pmid20722986en_US
dc.identifier.scopus2-s2.0-77957571278en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage970en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2010.01279.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18166
dc.identifier.volume36en_US
dc.identifier.wosWOS:000282379500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdverse Outcomesen_US
dc.subjectBody Mass Indexen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectSevere Pre-Eclampsiaen_US
dc.subjectInflammatory Responseen_US
dc.subjectNormal-Pregnancyen_US
dc.subjectWomenen_US
dc.subjectRisken_US
dc.subjectCytokinesen_US
dc.subjectOutcomesen_US
dc.subjectCrpen_US
dc.titleAssociation of maternal serum high sensitive C-reactive protein level with body mass index and severity of pre-eclampsia at third trimesteren_US
dc.typeArticleen_US

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