Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktas, Cevat
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T11:01:36Z
dc.date.available2024-06-12T11:01:36Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of quercetin (QE) on oxidative stress, apoptosis, and cell proliferation in the rat testis after streptozotocin (STZ)-induced diabetes. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the QE-treated group were given QE (15 mg/kg) once a day intraperitoneally for 8 weeks starting 3 days prior to STZ injection. At the end of the study, all animals were sacrificed. Testis tissues and blood samples were collected for histopathologic and biochemical analysis. QE treatment significantly decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities in testis tissues samples. The QE-treated rats in the diabetic group showed an improved histologic appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of QE-treated rats in the diabetic group. These results suggest that administration of QE is a potentially beneficial agent to reduce testicular damage in diabetic rats by decreasing oxidative stress. Crown Copyright (c) 2011 Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.fct.2011.11.051
dc.identifier.endpage725en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue3-4en_US
dc.identifier.pmid22166789en_US
dc.identifier.scopus2-s2.0-84856475646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage719en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2011.11.051
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20965
dc.identifier.volume50en_US
dc.identifier.wosWOS:000303284600042en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Diabetesen_US
dc.subjectTestisen_US
dc.subjectQuercetinen_US
dc.subjectTUNELen_US
dc.subjectAntioxidanten_US
dc.subjectTestosteronen_US
dc.subjectCell Nuclear Antigenen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectMalondialdehyde Levelsen_US
dc.subjectSeminiferous Tubulesen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectTesticular Tissueen_US
dc.subjectFree-Radicalsen_US
dc.subjectAntioxidanten_US
dc.subjectFlavonoidsen_US
dc.titleProtective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testisen_US
dc.typeArticleen_US

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